挤出滚圆法制备萘普生钠微丸效果分析

目的 应用挤出滚圆法制备萘普生钠微丸,研究微丸制备的处方和最佳工艺.方法 采用国产挤出滚圆机制备萘普生钠微丸,采用单因素考察和正交设计筛选处方和最优工艺条件,考察微丸的粉体学性质和收率.结果 用挤出滚圆技术制备的萘普生钠微丸圆整度好,大小均匀,体外释放度也较理想.结论 挤出滚圆机制备萘普生钠微丸工艺简便,硬度适宜,收率较高.

Effect Analysis on the Naproxen Sodium Pellets Prepared by Extrusion Spheronization

Objective To prepare naproxen sodium pellets by the extrusion spheronization technology,and to study the optimalprocess and formulation.Methods The naproxen sodium pellets were prepared using extrusion spheronization equipment,The optimalprocess and formulation were obtained on the studies of influenitial factors and L9(34) orthogonal design,the micromeritic properties and reception percentage of pellets were determined.Results The pellets prepared by extrusion spheronization were round,smooth and even.The dissolution test in vitro also was perfect.Conclusion The process of preparing pellets by extrusion spheronization was simple and feasible;The quality of the prepared pellets was excellent and the reception is high.