Neurokinin-1 receptors and spinal cord control of blood pressure in spontaneously hypertensive rats |
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| Authors: | Samuel G. Solomon Ida J. Llewellyn-Smith Jane B. Minson Leonard F. Arnolda John P. Chalmers Paul M. Pilowsky |
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| Affiliation: | a Department of Physiology, University of Sydney, Sydney, NSW 2006, Australia;b Departments of Physiology and Neurosurgery, Hypertension and Stroke Research Laboratories, Royal North Shore Hospital, Ground Floor, Block 3, St. Leonards, NSW 2065, Australia;c Department of Medicine and Centre for Neuroscience, Flinders University, SA 5042, Australia |
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| Abstract: | In this study we examined blood pressure and heart rate responses to intrathecal administration of a synthetic NK1-receptor agonist, H2N–(CH2)4–CO–Phe–Phe–Pro–NmeLeu–Met–NH2 (GR 73,632), in spontaneously hypertensive rats (SHR) and their progenitor strain, the Wistar–Kyoto rat (WKY). Sodium pentobarbitone anaesthetised rats with implanted intrathecal catheters were paralysed (pancuronium dibromide) and artificially ventilated. Injection of GR 73,632 at the T9 spinal level evoked dose-dependent increases in mean arterial pressure (MAP) in WKY and SHR. SHR had a lower MAP response threshold than WKY but increase in response with increasing dose was less in SHR than WKY. Biphasic blood pressure responses at high doses were observed in both strains. Prior administration of the NK1-receptor antagonist (3aR,7aR)-7,7-diphenyl-2-[1-imino-2(methoxyphenyl)ethyl] perhydroisoindol-4-one (RP 67,580) significantly reduced the pressor response in WKY but not SHR. The depressor response was not attenuated in either strain. |
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| Keywords: | Substance P Hypertension Sympathetic preganglionic neurons |
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