死亡2型糖尿病患者165例临床及病理分析

目的 分析尸体解剖糖尿病患者死亡的主要原因及主要病理改变特点.方法 对1988--2000年在解放军总医院死亡并行尸体解剖的165例糖尿病患者进行回顾性分析,并与同期死亡并行尸体解剖的165例非糖尿病患者进行比较.结果 临床诊断提示糖尿病患者冠心病、高血压、脑卒中、血脂异常、肾脏疾病的发生率均显著高于非糖尿病患者(P<0.05).病理资料提示糖尿病患者心肌病变的发生率69.6%(n=103)高于非糖尿病患者58.6%(n=85)(P=0.05).主动脉硬化分级评价结果显示糖尿病患者主动脉粥样硬化的程度大于非糖尿病组(P<0.05).两组问甲状腺、心脏、肝脏、肾脏、胰腺、肾上腺及脑重量差异无统计学意义(P>0.05).糖尿病患者的前3位主要病理死亡原因依次是恶性肿瘤39.4%(n=65),循环系统疾病35.2%(n=58)及呼吸系统疾病9.1%(n=15).结论 恶性肿瘤及循环系统疾病是糖尿病患者死亡的主要原因.

Abstract：

Objective To analyze the main mortality causes and pathological characteristics of type 2 diabetics with autopsy findings.Methods A total of 165 autopsy reports of type 2 diabetics were retrospectively reviewed and summarized at our institution.And 165 non-diabetics during the same period were analyzed similarly.Results The clinical data showed that type 2 diabetics had a higher risk for coronary heart disease,hypertension,stroke,hyperlipidemia and renal diseases than non-diabetics(P<0.05).The pathological data revealed that the rate of myocardium diseases in type 2 diabetics(69.6%,n=103)was higher than that in non-diabetics(58.6%,n=85).The evaluation of aortosclerotic grading demonstrated that the degree of arteriosclerosis in type 2 diabetics was severer than that in non-diabetics.The organ weight analysis showed the weight of thyroid,heart,liver,kidney,pancreas,adrenal gland and brain had no significant difference between type 2 diabetics and non-diabetics(P>0.05).The three major mortality causes were malignant neoplasms(39.4%,n=65),circulatory system diseases(35.2%,n=58)and respiratory system diseases(9.1%,n=15).Conclusion The onset of malignant tumors,especially gastrointestinal one,should be monitored closely during the prevention and treatment of cardiocerebrovascular diseases and complications.

Analysis of mortality causes for 165 type 2 diabetics: an autopsy study

Objective To analyze the main mortality causes and pathological characteristics of type 2 diabetics with autopsy findings.Methods A total of 165 autopsy reports of type 2 diabetics were retrospectively reviewed and summarized at our institution.And 165 non-diabetics during the same period were analyzed similarly.Results The clinical data showed that type 2 diabetics had a higher risk for coronary heart disease,hypertension,stroke,hyperlipidemia and renal diseases than non-diabetics(P<0.05).The pathological data revealed that the rate of myocardium diseases in type 2 diabetics(69.6%,n=103)was higher than that in non-diabetics(58.6%,n=85).The evaluation of aortosclerotic grading demonstrated that the degree of arteriosclerosis in type 2 diabetics was severer than that in non-diabetics.The organ weight analysis showed the weight of thyroid,heart,liver,kidney,pancreas,adrenal gland and brain had no significant difference between type 2 diabetics and non-diabetics(P>0.05).The three major mortality causes were malignant neoplasms(39.4%,n=65),circulatory system diseases(35.2%,n=58)and respiratory system diseases(9.1%,n=15).Conclusion The onset of malignant tumors,especially gastrointestinal one,should be monitored closely during the prevention and treatment of cardiocerebrovascular diseases and complications.