胃溃疡患者血清瘦素体重指数变化与幽门螺杆菌感染的关系研究

目的探讨胃溃疡患者的血清瘦素水平、体重指数(BMI)及其与幽门螺杆菌(Hp)感染的关系。方法将武汉大学人民医院2007年9月至2008年3月收治的31例Hp阳性的胃溃疡患者分为2组:抗Hp根治成功组22例,抗Hp根治失败组9例;12例Hp阴性胃溃疡患者给予抗溃疡治疗;14名正常人为对照组。治疗开始前及3个月后测定BMI、血清瘦素、症状评分、胃组织内白介素-8(IL-8)mRNA和蛋白质水平。结果治疗前Hp阳性胃溃疡组的IL-8mRNA和蛋白质 显著高于Hp阴性胃溃疡组、对照组(P<0.05)。治疗后,Hp阳性胃溃疡组IL-8mRNA和蛋白质表达、所有胃溃疡患者的血清瘦素和症状评分均降低(P<0.05),抗Hp根治成功患者、Hp阴性患者的BMI升高(P<0.05)。IL-8与瘦素或BMI改变无关,症状评分与血清瘦素和BMI变化均呈正相关(P<0.05)。结论胃溃疡患者症状的改善可能与其瘦素和BMI改变相关。

The relationship between leptin level BMI and helicobacter pylori infection in gastric ulcer.

Objective To investigate the leptin level and its relation with Hp infection in the gastric ulcer(GU).Methods Thirty-one Hp positive GU patients were chosen and divided into two groups,one group included 22 patients with successful eradication therapy on Hp and the other group included 9 patients with unsuccessful eradication therapy;12 Hp negative GU patients underwent anti-ulcer therapy;14 Hp negative normal persons were chosen as control.The BMI,serum leptin level,IL-8 mRNA and protein of gastric issue and symptom score were determined before and three month after the therapy.Results The expression of IL-8 protein and mRNA was obviously higher in Hp positive GU patients before therapy(P<0.05),but decreased after therapy(P<0.01).After therapy,the serum leptin level and symptom score decreased in all GU groups(P<0.05),while BMI obviously increased in patients(successful eradication on Hp)and Hp negative GU patients(P<0.05).No relation was found between IL-8 protein and leptin or BMI,but there was a positive relation between symptom score and leptin level or BMI.Conclusion It seems that improvement of symptom may be closely associated with the change of leptin level and BMI in gastric ulcer patients.