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| 心脏机械瓣膜置换术后华法林抗凝治疗的研究 | |
| 引用本文： | 高菲,侯明明,兰宝萍,曾志勇,宋洪涛. 心脏机械瓣膜置换术后华法林抗凝治疗的研究[J]. 中国药师, 2009, 12(2) |
| 作者姓名： | 高菲 侯明明 兰宝萍 曾志勇 宋洪涛 |
| 作者单位： | 1. 南京军区福州总医院药学科,福州,350025;沈阳药科大学药学院 2. 福建医科大学 3. 南京军区福州总医院心胸外科 4. 南京军区福州总医院药学科,福州,350025 |
| 摘 要： | 目的:探讨心脏机械瓣膜置换术后华法林临床抗凝治疗的影响因素、给药方法以及国际标准化比值(INR)监测。方法:对114例心脏瓣膜置换术后应用华法林抗凝治疗的患者的临床资料进行分析,记录年龄、性别、华法林剂量和INR值等,观察出血、栓塞等不良反应发生情况。结果:华法林维持剂量及达标时间个体差异较大,与年龄、性别、体重无关。华法林维持剂量范围1～6mg·d~(-1),71.1%的患者维持剂量为2.0～4.5mg·d~(-1),INR稳定达标时间为10～21d。结论:华法林抗凝治疗个体差异大,应在严密监测INR值条件下使用。 |
| 关 键 词： | 华法林 抗凝治疗 心脏机械瓣膜 国际标准化比值 |
Clinical Study of Warfarin Anticoagulation Therapy in Patients after Mechanical Heart Valve Replacement |
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| Gao Fei,Hou Mingming,Lan Baoping,Zeng Zhiyong,Song Hongtao. Clinical Study of Warfarin Anticoagulation Therapy in Patients after Mechanical Heart Valve Replacement[J]. China Pharmacist, 2009, 12(2) | |
| Authors: | Gao Fei Hou Mingming Lan Baoping Zeng Zhiyong Song Hongtao |
| Affiliation: | 1(1.Department of Pharmacy; Fuzhou General Hospital of Nanjing Military Region; Fuzhou 350025; China; 2.College of Pharmacy; Shenyang Pharmaceutical University; 3.Department of Pharmacy; Fujian Medical University; 4.Department of Cardiothoracic Surgery; Fuzhou General Hospital of Nanjing Military Region); |
| Abstract: | Objective:To study the influence factors of anticoagulation with warfarin in patients who has undergone artificial mechanical heart valve replacement were collected,suitable dose of warfarin and international normalized ratio(INR) monitoring.Method: The clinical data of 114 patients used warfarin anticoagulant therapy after artificial mechanical heart valve replacement.The age, gender,warfarin dose and INR value etc were recorded,and the adverse events included bleeding,embolism were observed.Result: The in... |
| Keywords: | Warfarin Anticoagulant therapy Mechanical heart valve International normalized ratio |
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