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CRIP1a switches cannabinoid receptor agonist/antagonist-mediated protection from glutamate excitotoxicity |
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| Authors: | Stauffer Brandon Wallis Kathleen T Wilson Steven P Egertová Michaela Elphick Maurice R Lewis Deborah L Hardy Lori Redmond |
| Affiliation: | a Department of Pharmacology and Toxicology, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA 30912, USA b Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, Columbia, SC 29208, USA c Queen Mary University of London, School of Biological & Chemical Sciences, London E1 4NS, UK |
| Abstract: | A shared pathology among many neurological and neurodegenerative disorders is neuronal loss. Cannabinoids have been shown to be neuroprotective in multiple systems. However, both agonists and antagonists of the CB1 cannabinoid receptor are neuroprotective, but the mechanisms responsible for these actions remain unclear. Recently a CB1 receptor interacting protein, CRIP1a, was identified and found to alter CB1 activity. Here we show that in an assay of glutamate neurotoxicity in primary neuronal cortical cultures CRIP1a disrupts agonist-induced neuroprotection and confers antagonist-induced neuroprotection. |
| Keywords: | CRIP1a CB1 cannabinoid receptor Cell death Neuroprotection Glutamate toxicity |
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