|
|||||
|
|
| 导数紫外光谱法测定人血浆中三唑仑的血药浓度! | |
| 引用本文： | 周波林. 导数紫外光谱法测定人血浆中三唑仑的血药浓度![J]. 中国医药导报, 2014, 0(23): 22-25 |
| 作者姓名： | 周波林 |
| 作者单位： | 广西医科大学第九附属医院广西壮族自治区北海市人民医院药剂科,广西北海536000 |
| 基金项目： | 广西壮族自治区北海市科学研究与技术开发计划项目（编号：北科合201047029）. |
| 摘 要： | 目的：建立测定人血浆中三唑仑浓度的一阶导数分光光度法，为临床应用提供技术参考。方法采用一阶导数光谱法在232.0 nm波长处测定人血浆中三唑仑浓度。结果三唑仑在2.55~15.30μg/mL范围呈良好线性关系；其回归方程为D=1.3487×10-3C＋3.7748×10-3（r =0.9965）；平均回收率为101.53豫，RSD=2.12豫（n=5）。结论该法操作简单，测定结果准确，适用于三唑仑血药浓度的监测。 |
| 关 键 词： | 三唑仑 血药浓度 一阶导数光谱法 治疗药物监测 |
Determination of Triazolam in human plasma by derivative spectropho-tometry |
|
| ZHOU Bolin. Determination of Triazolam in human plasma by derivative spectropho-tometry[J]. China Medical Herald, 2014, 0(23): 22-25 | |
| Authors: | ZHOU Bolin |
| Affiliation: | ZHOU Bolin( Department of Pharmacy, the Ninth Affiliated Hospital of Guangxi Medical University Beihai People＇s Hospital, Guangxi Zhuang Autonomous Region, Beihai 536000, China) |
| Abstract: | Objective To develop first order derivative spectrophotometry for the determination of Triazolam concentra-tion in human plasma to provide the technical reference for its clinical application. Methods The first order derivative spectrophotometry was performed at the wavelength of 232.0 nm. Results Triazolam showed a good linear relationship within a ranger of 2.55-15.30 μg/mL, the regression equation was D=1.3487×10-3C＋3.7748×10-3 （r=0.9965）; the aver-age recovery was 101.53%, RSD=2.12%（n=5）. Conclusion This method is simple to operate and accurate in the detec-tion results, and can be applied in the analysis of Triazolam in human plasma. |
| Keywords: | Triazolam Plasma drug concentration First order derivative spectrophotometry Therapeutic drug moni-toring |
| 本文献已被 CNKI 维普 等数据库收录！ | |