702例抗结核药物所致不良反应分析

目的分析结核病专科医院住院患者抗结核药物所致药物不良反应(ADR)的发生情况。方法由结核科专业医师提供病程记录,医嘱单,实验室检查及辅助检查结果,回顾性分析抗结核药物所致不良反应的发生情况。结果1 222例住院患者中发生不良反应702例(57.4%),共25种。287例合并多种不良反应。总的不良反应为1 097例次。其中332例(332/1 222,27.17%)因不良反应严重需要调整治疗方案。最多见的不良反应为血尿酸增高,占所有不良反应的37.28%(409/1 097)。96%的不良反应发生在60 d之内。结论应重视抗结核药物所致的不良反应,加强对相关专业人员的培训和对患者的宣教,对具有危险因素的人群采取个体化治疗并密切监测以便及时发现各种不良反应,需进一步完善抗结核药物所致不良反应的呈报系统。

Analysis of the adverse drug reactions of anti-tuberculosis drugs in 702 cases

Objective To analyze the anti-tuberculosis adverse drug reactions(ADRs) occurred in hospital patients in special tubercular hospital. Methods Retrospectively studied the incidence rate of anti-tubercular adverse drug reactions through admission document,medical orders,laboratory examination and diagnostic examination offered by tuberculosis specialists. Results Of 1222 patients,702 cases experienced 25 types of ADRs.287 cases experienced more than one types of ADRs.The total number of the ADRs was 1097.Treatment regimens were required modification in 332 of 1222 patients(27.17%) because of severe adverse reactions.Hyperuricemia was the most common ADRs.Among 1079 ADRs,409 were hyperuricemia(37.28%).96% ADRs occurred in 60 days. Conclusion The ADRs should be taken into consideration.It is important to reinforce the training to the doctors and to intensify the propagandizer to the patients.Individual treatment should be adapted to every patient. Closer monitored during the process of treatment in order to modify the dosage and the regimen.The anti-tuberculosis ADRs reporting system in hospital should be improved.