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Patch testing with beryllium alloy samples in guinea pigs
Authors:Daniè  le,Zissu ,Sté  phane,Binet Claude,Cavelier
Affiliation:Institut National de Recherche et de Sécurité, Avenue de Bourgogne, 54501 Vandoeuvre, France
Abstract:An experimental study was conducted in guinea pigs for the predictive assessment of the beryllium alloy hazard in occupational exposure of the skin to beryllium compounds. Guinea pigs were sensitized to beryllium sulfate according to the maximized Magnusson and Kligman test, and challenged with beryllium alloys and metallic copper, beryllium and aluminum samples. Results showed a delayed skin hypersensitivity reaction in 30 to 60% of pre-sensitized guinea pigs challenged with copper-beryllium alloys and aluminum-beryllium alloy. An inflammatory follicular reaction was induced by copper in both controls and pre-sensitized guinea pigs.
Keywords:guinea pigs    Magnusson and Kligman test    beryllium sulfate    delayed skin hypersensitivity    beryllium alloys
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