国产吉西他滨联合顺铂治疗晚期非小细胞肺癌临床分析

目的:观察国产吉西他滨(泽菲)联合顺铂治疗晚期非小细胞肺癌(NSCLC)的近期疗效及毒副反应。方法:有明确病理和/或细胞学诊断的晚期NSCLC病例30例,泽菲1.0g/m2,静脉滴注,d1、d8,顺铂80mg/m2,静脉滴注,d1,以21天为1周期,连用2个周期后评价疗效。结果:全组30例均可评价,CR 0,PR 13例,NC 9例,PD 7例。有效率为43.33%(13/30),主要毒副反应为胃肠反应和血液毒性,III~IV级白细胞和血小板下降分别为21.74%和16.67%。结论:泽菲联合顺铂治疗NSCLC有较好疗效,毒性较小可以耐受。

Combined chemotherapy with domestic gemcitabine(ZEFEL) plus cisplatin in the treatment of advanced non- small cell lung cancer

Objective:To evaluate effect of domestic gemcitabine(ZEFEI) plus cisplatin on non-small cell lung cancer(NSCLC).Methods: Thirty cases of cytologically and pathologically confirmed adcanced NSCLC were treated with combined chemotherapy including domestic gemcitabine and cisplatin.Gemcitabine1.0g/m~2 IV,day 1 and day 8,cisplatin 80mg/m~2 IV d1,a cycle was 21 days.Effect was eraluated after 2 cycles. Results: All cases were evaluated.There was no CR in patients treated with the regimen,PR 13,NC 9 cases,PD 7 cases.The response rate was 43.33%(13/30).The side effects were mainly myleosuppression and digestive tract rection.Grade III~IV leucopenia and thrombocytopenia were 21.74% and 16.67%.Conclusion:The combined chemotherapy is effective and safe in the treatment of advanced NSCLC and the adverse effects are tolerable.