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Allogeneic hematopoietic stem cell transplantation against recurrent rhabdomyosarcoma
Authors:Ohta Hideaki  Hashii Yoshiko  Yoshida Hisao  Kusuki Shigenori  Tokimasa Sadao  Yoneda Akihiro  Fukuzawa Masahiro  Inoue Nami  Hara Junichi  Kusafuka Takeshi  Ozono Keiichi
Affiliation:Department of Pediatrics, Osaka University Graduate School of Medicine, Suita, Japan. ohta@ped.med.osaka-u.ac.jp
Abstract:
The prognosis of high-risk rhabdomyosarcoma (RMS) with metastatic or recurrent disease remains poor. We report a 6-year-old girl who successfully underwent allogeneic hematopoietic stem cell transplantation against recurrent metastatic alveolar RMS. The disease recurred at distant lymph node metastasis with bone marrow involvement. After chemotherapy and radiotherapy for the metastatic site, she underwent allogeneic bone marrow transplantation during complete remission from her 5/8 HLA-matched father. She developed acute graft-versus-host disease after preemptive donor lymphocyte infusion and remains in a disease-free condition for 31 months after transplantation. A graft-versus-tumor effect through allogeneic immune cells might produce a beneficial effect for high-risk RMS.
Keywords:
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