Decreased energy demanding processes in the frontal lobes of schizophrenics due to neuroleptics? A P-magneto-resonance spectroscopic study期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Decreased energy demanding processes in the frontal lobes of schizophrenics due to neuroleptics? A P-magneto-resonance spectroscopic study

Authors:	Hans-Peter Volz Reinhard Rzanny Grit R ger Gabriele Hü bner Ilonka Kreitschmann-Andermahr Werner Alois Kaiser Heinrich Sauer

Affiliation:	^a Psychiatric Department, University of Jena, Philosophenweg 3, Jena, D-07740 Jena, Germany ^b Institute of Diagnostic and Interventional Radiology, University of Jena, Philosophenweg 3, Jena, D-07740 Jena, Germany

Abstract:	In the present investigation on ³¹P-magneto-resonance spectroscopic parameters in the frontal lobe, we found phosphocreatine levels and the ratio phosphocreatine/adenosine triphosphate to be increased (12.62±1.98% resp. 0.31±0.06) in 50 neuroleptic-treated schizophrenics, whereas no differences were detected in 10 neuroleptic-free patients (11.66±2.57% resp. 0.29±0.08) compared to 36 controls (11.37±1.45 resp. 0.29±0.04). This result points to a major role of neuroleptics in the metabolism of high-energy phosphates.

Keywords:	³¹Phosphorus magnetic resonance spectroscopy Schizophrenia Neuroleptics Frontal lobe
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