Cyclin E在乳腺癌组织中的表达及其临床意义

目的:探讨CyclinE的表达在乳腺癌的发生、转移和复发中的作用。方法:通过免疫组化SP法检测CyclinE在69例乳腺癌组织中的原位表达,并对肿瘤临床分期与其表达结果做相关性分析。结果:CyclinE在乳腺癌中的表达率为47.8%,其与肿瘤临床分期及淋巴结转移呈正相关。CyclinE在不同临床分期的乳腺癌组织中过表达率的差异具有显著性意义(χ2=8.154,P<0.05)。在乳腺癌患者淋巴结转移组,CyclinE蛋白的阳性表达率为64.52%,远高于无淋巴结转移组的阳性率36.84%(χ2=5.231,P<0.05)。结论:CyclinE的表达可预测乳腺癌患者淋巴结转移和复发,并可作为推断预后的重要指标之一。

Expression of Cyclin E in Tissues of Breast Cancer

Objective To detect the expression level of Cyclin E protein in tissues of breast cance.Then to investigate the relationship between the expression of Cyclin E and the occurrence、metastasis and recurrence of breast cancer.Methods The expression level of Cyclin E protein in 69 breast cancer patients was detected by immunohistochemistry.Results The expression rate in 69 tissuses of breast cancer was 47.8%.The expression level of Cyclin E protein had a positive correlation with the clinical stage and metastasis.There was a significance difference with the expression level in different clinical stage patients(χ2=8.154,P<0.05).The expression rate in patients with lymphaden metastasis was 64.52%.It was much higher than that in patients no metastas is 36.84%.The significance difference was showed between those patients who had lymphaden metastasis and those who had no(χ2=5.231,P<0.05).Conclusion The findings show us that the expression of Cyclin E could be one of useful index to predict the lymphaden metastasis and the recurrence of breast carcinoma.