铝碳酸镁和莫沙比利治疗胆汁反流性胃炎20例临床观察

目的：观察铝碳酸镁和莫沙比利对胆汁反流性胃炎疗效。方法：40例胆汁反流性胃炎，经胃镜检查证实有胆汁反流，并随机分为两组：T组20例服用铝碳酸镁，1g／次,3次／d。T M组20例同时服用铝碳酸镁和莫沙比利，莫沙比利5mg／次，3次／d；铝碳酸镁服法同上。治疗4周后观察腹痛、腹胀、呕吐胆汁等症状变化。结果：治疗后2组患者症状明显减轻(P＜0．01)，有效率均为100％。结论：铝碳酸镁可结合胃内胆酸，有效缓解胆汁反流性胃炎症状，莫沙比利减少肠内胆汁反流，它们均为治疗胆汁反流性胃炎的有效药物。

The clinic efficacy of hydrotalcid and mosapride in treating bile reflux gastritis of 20 patients

Objective: To evaluate the effect of hydrotalcid and mosapride in bile-reflux gastritis.Methods: Forty patients with bile-reflux gastritis by gastroscope examination were divided into 2 groups equally at random: T group 20 patients which were treated with hydrotalcid 1.0g, three times a day. T+M group 20 patients which were treated with hydrotacid and mosapride, mosapride 5.0mg, three times a day; hydrotalcid 1.0g ,three times a day. The change of the symptoms including abdominal pain, abdominal distention and bile vomitus were vestigated before and after four weeks treatment.Results: The severity of all the symptoms in the two groups decreased greaty after treatment(P<0.01), the total effective rates was all 100%.Conclusions: Hydrotalcid can bind with intragastic bile, and effective decrease the symptoms of bile-reflux gastritis; Mosapride can reduce bile-reflux of duodenum. They are effective drugs in treating bile-reflux gastritis.