| β-细辛醚在大鼠体内的药代动力学 |
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| 引用本文： | 吴宏斌,方永奇.β-细辛醚在大鼠体内的药代动力学[J].药学学报,2004,39(10):836-838. |
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| 作者姓名： | 吴宏斌 方永奇 |
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| 作者单位： | 广州中医药大学,第一附属医院,广东,广州,510405 |
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| 摘 要： | 目的了解石菖蒲主要成分β-细辛醚的药代动力学特征。方法以HPLC法测定ig大鼠血清和各器官（脑、心、肺、肾、肝）中β-细辛醚的浓度，把器官当作相对独立的系统，用DAS软件进行药代动力学分析。结果β-细辛醚在大鼠体内的药代动力学过程属一级一室动力学模型，血清半衰期为54 min；达峰时间12 min；达峰浓度3.19 mg·L-1。各器官与血清有相似的动力学过程。结论β-细辛醚在体内吸收、分布、代谢较迅速，极易透过血脑屏障，大脑是重要的分布器官。
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| 关 键 词： | 石菖蒲 β-细辛醚 药代动力学 HPLC |
| 收稿时间： | 2003-10-09 |
Pharmacokinetics of β-asarone in rats |
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| WU Hong-bin,FANG Yong-qi.Pharmacokinetics of β-asarone in rats[J].Acta Pharmaceutica Sinica,2004,39(10):836-838. |
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| Authors: | WU Hong-bin FANG Yong-qi |
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| Institution: | First Affiliated Hospital of Guangzhou University of TCM, Guangzhou 510405, China. benzwoo3000@163.com |
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| Abstract: | AIM: To study the pharmacokinetics of beta-asarone in rats. METHODS: The concentration of beta-asarone in serum and organs were measured by HPLC after i.g. administration, the pharmacokinetics was analyzed with DAS software regarding the organs as independent system. RESULTS: The pharmacokinetics of beta-asarone can be described as first order process of one-compartment model. In the serum, T(1/2), Tpeak and Cmax were 54 min, 12 min and 3.19 mg x L(-1), respectively. The procedure in the organs was similar to that in serum. CONCLUSION: The absorption, distribution and elimination of beta-asarone are very rapid, and it is easy to pass through blood brain barrier. Brain is an important organ of distributing of beta-asarone. |
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| Keywords: | β-asarone pharmacokinetics HPLC Acorus tatarinowii Schott |
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