中药六味安消联合左氧氟沙星根除幽门螺杆菌疗效观察

目的观察中药六味安消联合左氧氟沙星方案根除Hp的疗效。方法选择Hp阳性慢性胃炎250例,随机分为A组128例和B组122例,A组口服埃索美拉唑20mg加左氧氟沙星200mg,2次/d,1周,六味安消胶囊2.0g,3次/d,2周。B组口服埃索美拉唑片20mg加阿莫西林分散片1g加克拉霉素500mg,2次/d,1周。疗程结束1个月后行14C尿素呼气验检测Hp。结果A组和B组HP根除率分别为84.2%和73.0%,差异有显著性（P〉0.05）;A组和B组临床有效率分别为97.5%和94.8%,差异无显著性（P〉0.05）。结论六味安消联合左氧氟沙星疗法比传统标准三联疗法的Hp根除率高,且与传统三联临床疗效相当,可作为根除Hp的治疗方案之一。

The clinical observation for eradication of Helicobacter pylori with traditional medicine liuweianxiao and levofloxacin

Objective To investigate the efficacy of eradication of Helicobacter pylori（H pylori） with traditional medicine LiuWeiAnXiao and levofloxacin.Methods A total of 250 H pylori positive patients suffering from chronic gastritis were randomly allocated into two groups.Group A 128 patients received esomeprazole 20 mg ＋ levofloxacin200 mg,twice daily for 1 wk,LiuWeiAnXiao 2 g,three times daily,for 2 wk.group B 122 patients received esomeprazole 20 mg ＋ amoxicillin 1 g ＋ clarithromycin 500 mg,twice daily for 1 wk. H pylori status was assessed 4 weeks after the end of treatment by 14C urea breath test.Results H prior eradication rates were 84.2% in group A and 73.0% in group B,respectively,and the difference was significant （P〈0.05）.The total effective rates were 97.5% and 94.8% in two groups,respectively,and the difference was not significant （P〉0.05）.Conclusion The therapy with LiuWeiAnXiao and levofloxacin has a higher H prior eradication rates than traditional trigeminy therapy,and a same clinic effective to traditional trigeminy therapy.it is a feasible H pylori eradication regimen.