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| 鲍曼不动杆菌耐药机制的研究及进展 | |
| 引用本文： | 杨彬艺,姚冬梅. 鲍曼不动杆菌耐药机制的研究及进展[J]. 实用预防医学, 2019, 26(6): 766-769. DOI: 10.3969/j.issn.1006-3110.2019.06.038 |
| 作者姓名： | 杨彬艺 姚冬梅 |
| 作者单位： | 1.中南大学湘雅医学院, 湖南 长沙 410013; 2.中南大学湘雅二医院, 湖南 长沙 410011 |
| 摘 要： | 鲍曼不动杆菌(Acietobacter baumannnii)属于革兰阴性杆菌,鲍曼不动杆菌耐药相关机制十分复杂,其中泛耐药鲍曼不动杆菌(extensively drug-resistant Acinetobacter baumannii,XDRAB)和全耐药鲍曼不动杆菌(pan drug-resistant Acinetobacter baumannii,PDRAB)更为复杂。由于药物灭活酶、外排泵等机制导致其对多种抗生素耐药,因此临床治疗变得十分困难,患者病死率比较高。本次研究主要是对近年来发现鲍曼不动杆菌的耐药机制的研究进展进行综述,并对当前广泛使用的治疗手段进行总结。 |
| 关 键 词： | 鲍曼不动杆菌 进展 耐药机制 外排泵 |
| 收稿时间： | 2018-10-22 |
Research and advances on resistance mechanism of Acinetobacter baumannii |
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| YANG Bin-yi,YAO Dong-mei. Research and advances on resistance mechanism of Acinetobacter baumannii[J]. Practical Preventive Medicine, 2019, 26(6): 766-769. DOI: 10.3969/j.issn.1006-3110.2019.06.038 | |
| Authors: | YANG Bin-yi YAO Dong-mei |
| Affiliation: | 1. Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, China; 2. The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China |
| Abstract: | Acinetobacter baumannii (A. baumannii) belongs to Gram-negative bacilli, and its related resistance mechanism is very complicated, especially in extensively drug-resistant Acinetobacter baumannii (XDRAB) and pan drug-resistant Acinetobacter baumannii (PDRAB).A. baumannii is resistant to a variety of antibiotics due to the mechanisms of drug inactivation enzymes and efflux pumps; and hence, clinical treatment has become very difficult, with a high mortality rate in the patients. This study is mainly to review the research progress of resistance mechanism ofA. baumannii in recent years and summarize the currently widely used treatment methods. |
| Keywords: | Acinetobacter baumannii advance resistance mechanism efflux pump |
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