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| CDH1基因多态与结直肠癌和肝癌发生、进展的关系 | |
| 引用本文： | 朱忠政,丛文铭,王爱忠,贾杭若,金夏祥,何向蕾,朱冠山.CDH1基因多态与结直肠癌和肝癌发生、进展的关系[J].临床与实验病理学杂志,2008,24(5). |
| 作者姓名： | 朱忠政 丛文铭 王爱忠 贾杭若 金夏祥 何向蕾 朱冠山 |
| 作者单位： | 1. 解放军第113医院,病理科,宁波,315040;第二军医大学东方肝胆外科医院病理科,上海,200438 2. 第二军医大学东方肝胆外科医院病理科,上海,200438 3. 解放军第113医院,病理科,宁波,315040 4. 宁波市,李惠利医院病理科,宁波,315041 5. 阿斯利康中国创新中心,上海,201203 |
| 基金项目： | 国家自然科学基金，江苏省南京军区医学科学技术研究计划 |
| 摘 要： | 目的 探讨CDH1基因C-160A多态与结直肠癌(colorectal cancer,CRC)和肝细胞癌(hepatocellular carcinoma,HCC)发病风险和肿瘤分级分期的关系.方法 采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法 检测374例CRC与324名对照以及180例HCC与209名对照的CDH1 C-160A基因型分布及差异.结果 CDH1 C-160A基因型分布在CRC-对照和HCC-对照人群间差异均无显著性(P>0.05).然而,高TNM分期(Ⅲ Ⅳ)CRC组中A基因型(CA AA)频率显著低于低TNM分期者(Ⅰ Ⅱ)(P=0.008);淋巴结转移阳性CRC组中A基因型频率显著低于转移阴性者(P=0.016);远处转移阳性CRC组中A基因型频率也低于转移阴性者,但差异无统计学意义(P=0.169).高T分期(T2～T4)HCC组中A基因型频率低于T1期者,但差异未达到统计学意义(P=0.066).结论 CDH1 C-160A与CRC和HCC的发病风险无关,但-160A可能对CRC肿瘤进展具有保护作用. |
| 关 键 词： | 结直肠肿瘤 肝肿瘤 基因多态 遗传易感性 |
Association of CDH1 polymorphism with tumorigenesis and progression of colorectal cancer and hepatocellular carcinoma |
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| ZHU Zhong-zheng,CONG Wen-ming,WANG Ai-zhong,JIA Hang-ruo,JIN Xia-xiang,HE Xiang-lie,ZHU Guan-shan.Association of CDH1 polymorphism with tumorigenesis and progression of colorectal cancer and hepatocellular carcinoma[J].Chinese Journal of Clinical and Experimental Pathology,2008,24(5). | |
| Authors: | ZHU Zhong-zheng CONG Wen-ming WANG Ai-zhong JIA Hang-ruo JIN Xia-xiang HE Xiang-lie ZHU Guan-shan |
| Institution: | 1Department of Pathology;No 113 Hospital of People's Liberation Army;Ningbo 315040;China;2Department of Pathology;Eastern Hepatobiliary Surgery Hospital;Second Military Medical University;Shanghai 200438;3Department of Pathology;Li Hu-li Hospital;Ningbo 315041;4Innovation Center China;Astra Zeneca Global R&D;Shanghai 201203;China |
| Abstract: | Purpose To investigate the possible association between the functional C-160A polymorphism of CDH1 gene and the occurrence,tumor grade and stage of colorectal cancer(CRC) and hepatocellular carcinoma(HCC) in a Chinese population.Methods The CDH1 C-160A genotype was determined by a PCR-based restriction fragment length polymorphism(RFLP) method in 374 CRC cases and age-,sex-matched 324 controls,and in 180 HCC cases and age-,sex-matched 209 controls.Odds ratios(OR) for cancer and 95% confidence intervals(CI) ... |
| Keywords: | CDH1 |
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