Involvement of OSP/claudin-11 in oligodendrocyte membrane interactions: role in biology and disease |
| |
Authors: | Bronstein J M Tiwari-Woodruff S Buznikov A G Stevens D B |
| |
Affiliation: | Departments of Neurology and the Brain Research Institute, UCLA School of Medicine, Los Angeles, CA 90095, USA. jbronste@ucla.edu |
| |
Abstract: | Oligodendrocyte-specific protein (OSP/claudin-11) is a four transmembrane protein concentrated in central nervous system myelin. Recent evidence has emerged suggesting that OSP/claudin-11 is involved in membrane interactions at tight junctions and with the extracellular matrix. OSP/claudin-11 seems to modulate proliferation and migration of oligodendrocytes presumably through these interactions. Furthermore, evidence is presented implicating OSP/claudin-11 as an autoantigen in the development of autoimmune demyelinating disease. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|