Therapeutic approaches for actinic cheilitis: therapeutic efficacy and malignant transformation after treatment |
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| Affiliation: | 1. CS Praza do Ferrol, EOXI Lugo, Cervo, e Monforte, Galician Health Service, Lugo, Spain;2. School of Medicine & Dentistry, University “Santiago de Compostela”, Coruña, Spain;3. Department of Surgery and Medical-Surgical Specialities, University of Oviedo, Oviedo, Spain;4. Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain;1. Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong;2. Oral and Maxillofacial Radiology, Applied Oral Sciences and Community Dental Care, Faculty of Dentistry, The University of Hong Kong, Hong Kong;3. Department of Oral and Maxillofacial Surgery and Diagnosis, International Islamic University Malaysia, Selangor, Malaysia;1. Department of Oral and Maxillofacial Surgery, University Hospital La Princesa, Autónoma University, Madrid, Spain;2. Department of Oral and Maxillofacial Surgery, University Hospital Montepríncipe, San Pablo CEU University, Madrid, Spain |
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| Abstract: | Actinic cheilitis (AC) is a sun-induced premalignant lesion. AC is a clinical term housing a wide pathological spectrum ranging from hyperkeratosis to invasive squamous cell carcinoma. The aim of this systematic review was to examine the therapeutic efficacy of different approaches in clinical, histological, and cosmetic terms, and the malignization rate after treatment. A systematic search was undertaken in October 2016 and updated in April 2019 at MEDLINE (from 1966), Embase (from 1980), and Proceedings Web of Science (Conference Proceedings Citation Index-Science (CPCI-S) from 1990) databases. The search strategy was ((“actinic” or “solar”) AND (“cheilitis”)) using both medical subject headings (MeSH) and freetext. A total of 392 potentially eligible reports were identified. After the selection procedure, 20 articles were included. It was concluded that surgical treatment is the first line of treatment for AC and has proved useful for the clinical and pathological control of the disorder. However, there was no evidence of effective treatment in preventing malignant transformations. Non-surgical procedures showed less consistent results, although drug therapy may improve the results obtained by other therapeutic approaches. |
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| Keywords: | actinic cheilitis treatment malignization squamous cell carcinoma systematic review |
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