Drug-induced enterocolitis syndrome (DIES) in a 10-year-old girl |
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| Affiliation: | 1. Service de pneumologie et allergologie pédiatriques, hôpital Necker-Enfants Malades, AP–HP, Paris, France;2. Service de pédiatrie générale, hôpital Ambroise Paré, AP–HP, Boulogne-Billancourt, France;3. Université Paris Descartes, Paris, France;1. Pediatric Allergy Unit, Severo Ochoa Universitary Hospital, Leganés, Spain;2. Pediatric Gastroenterology Unit, Severo Ochoa Universitary Hospital, Leganés, Spain;3. Pediatric Allergy Unit, Villalba General Hospital, Villalba, Spain;4. Pediatric Gastroenterology Unit, Rey Juan Carlos Universitary Hospital, Móstoles, Spain;1. Department of Emergency and Critical Care Medicine, The University of Tokyo Hospital, Japan;2. Department of Health Policy and Technology Assessment, National Institute of Public Health, Japan;3. Department of Emergency and Critical Care Medicine, Ohta Nishinouchi Hospital, Japan;1. School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China;2. Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden;3. Department of Science and Education, First Affiliated Hospital of Jinan University, Guangzhou, China |
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| Abstract: | We report the case of a child presenting with an adverse drug reaction highly suggestive of drug-induced enterocolitis syndrome (DIES) to amoxicillin (AMX). A 10-year-old girl developed repetitive vomiting and pallor without cutaneous or respiratory symptoms 2 h after AMX intake. DIES is not a well-described entity, and very few data are available in the literature. In the absence of an existing definition, the diagnosis of DIES can only be suspected and is based on its homology with food protein-induced enterocolitis (FPIES). The major criterion is the recurrence of repetitive and often incoercible vomiting occurring within 1–4 h of ingestion of the culprit food in the absence of IgE-mediated allergic classic skin and respiratory symptoms. Once the diagnosis of DIES to AMX is suspected, an open challenge with AMX should be undertaken with caution, under medical supervision in a day hospital unit because of the risk of severe recurrence. Once the diagnosis is confirmed, AMX should be contraindicated to avoid severe reactions. |
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| Keywords: | Drug-induced enterocolitis syndrome Antibiotic Food protein-induced enterocolitis syndrome |
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