| 离体大鼠肠道菌群对类叶升麻苷代谢的研究 |
| |
| 引用本文： | 张文秀,杨彪,胡玉梅,孟兆青,黄文哲,王振中,萧伟.离体大鼠肠道菌群对类叶升麻苷代谢的研究[J].中国中药杂志,2016,41(8):1541-1545. |
| |
| 作者姓名： | 张文秀 杨彪 胡玉梅 孟兆青 黄文哲 王振中 萧伟 |
| |
| 作者单位： | 江苏康缘药业股份有限公司, 江苏 连云港 222001;中国药科大学, 江苏 南京 210009,江苏康缘药业股份有限公司, 江苏 连云港 222001,江苏康缘药业股份有限公司, 江苏 连云港 222001,江苏康缘药业股份有限公司, 江苏 连云港 222001,江苏康缘药业股份有限公司, 江苏 连云港 222001,江苏康缘药业股份有限公司, 江苏 连云港 222001,江苏康缘药业股份有限公司, 江苏 连云港 222001 |
| |
| 基金项目： | 国家"重大新药创制"科技重大专项(2013ZX09402203) |
| |
| 摘 要： | 在离体培养的大鼠肠道菌群中加入类叶升麻苷进行厌氧孵育。采用HPLC监测类叶升麻苷在不同孵育时间点的变化,同时运用HPLC-Q-TOF-MS鉴定类叶升麻苷的代谢产物。结果表明离体的大鼠肠道菌群可以对类叶升麻苷进行代谢,代谢产物分别是3,4-二羟基苯乙醇、咖啡酸和3-(3'-羟苯基)丙酸。
|
| 关 键 词： | 类叶升麻苷 肠道菌群 代谢产物 液质联用 |
| 收稿时间： | 2015/11/30 0:00:00 |
Effect of rat intestinal flora in vitro on metabolites of acteoside |
| |
| ZHANG Wen-xiu,YANG Biao,HU Yu-mei,MENG Zhao-qing,HUANG Wen-zhe,WANG Zhen-zhong and XIAO Wei.Effect of rat intestinal flora in vitro on metabolites of acteoside[J].China Journal of Chinese Materia Medica,2016,41(8):1541-1545. |
| |
| Authors: | ZHANG Wen-xiu YANG Biao HU Yu-mei MENG Zhao-qing HUANG Wen-zhe WANG Zhen-zhong and XIAO Wei |
| |
| Institution: | Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China;China Pharmaceutical University, Nanjing 210009, China,Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China,Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China,Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China,Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China,Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China and Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China |
| |
| Abstract: | Acteoside was used for anaerobic incubation with rat intestinal flora in vitro. HPLC was used to detect the changes of acteoside at different incubation time points and HPLC-Q-TOF-MS was used to identify the metabolites of acteoside. The results showed that acteoside could be metabolized by rat intestinal flora in vitro and the metabolites were 3,4-dihydroxyphenyl acid, caffeic acid and 3-(3''-hydroxyphenyl) propionic acid. |
| |
| Keywords: | acteoside intestinal flora metabolites LC-MS |
| 本文献已被 CNKI 等数据库收录！ |
|
