纳米银抗菌钛种植体对成纤维细胞的影响

目的考查纳米银抗菌钛板对成纤维细胞早期生物学行为的影响。方法将原代培养的人牙龈成纤维细胞接种于纳米银抗菌钛种植体表面,通过对样品表面细胞形态学观察和细胞增殖的检测分析该表面对成纤维细胞早期生物学行为的影响。结果和对照组相比,成纤维细胞在纳米银抗菌钛种植体表面早期铺展形态有差异,而增殖差异无统计学意义（P〉0.05）。结论经过纳米银改性后的钛片对成纤维细胞早期生物学行为无不良影响。

Silver Nanoparticles Modified Titanium Surface Exhibits Cell Compatibility.

Objective Develop a novel antibacterial titanium implant surface and to test its biological performance. Methods A silver nanoparticle-modified titanium（Ti-nAg） surface was prepared using silanization method, In the present study, using the scanning electron microscopy and MTT assay, we assessed differentiation and proliferation of human gingival fibroblasts （hGFs）respectively, on our silver nanoparticle-modified titanium （Ti-nAg） plate. Results The results demonstrate that the Ti-nAg do not show any cytotoxicity to the fibroblasts. Conclusion Our data indicate that Ti-nAg is a novel material with both good antibacterial properties and uncompromised cytocompatibility,which can be used as an implanted biomaterial.