乙型肝炎病毒母婴垂直传播与乙肝抗原及乙肝DNA载量的关系研究

目的研究妊娠合并乙型肝炎病毒感染孕妇母婴垂直传播相关因素。方法选择妊娠合并乙型肝炎病毒感染孕妇100例作为研究对象,对患者病病历资料作回顾性分析。结果 HBsAg单阳性孕妇母婴垂直传播几率1.75%较HBsAg、HBeAg双阳性母婴垂直传播几率46.51%低,差异有统计学意义（P〈0.05）。外周血HBV DNA≥106copies/mL的产孕妇分娩后胎儿HBV DNA阳性率50.0%较HBV DNA≤105copies/mL和105copies/mL。

Study on the Correlation of Mother-to-infant Vertical Transmission of Hepatitis B Virus with Hepatitis B Antigen and HBV DNA Load

Objective To investigate the relative factors of mother-to-infant vertical transmission of hepatitis B virus. Methods100 pregnant women with hepatitis B virus infection were selected as the subjects. And the medical records of them were analyzed retrospectively. Results The probability of mother-to-infant vertical transmission of the pregnant women with positive HBsAg was1.75%, lower than 46.51% of the pregnant women with double positive HBsAg, HBeAg, the difference was statistically significant（P 0.05）. The fetal HBV DNA positive rate of the pregnant women with HBV DNA ≥ 106copies/ml in peripheral blood after childbirth was 50.0%, higher than HBV DNA≤105copies/ml and 105copies/ml 〈HBV DNA〈 106copies/ml group, the difference was statistically significant（P〈0.05）. Conclusion HBsAg single positive, HBsAg /HBeAg double positive and high load HBV DNA in the maternal blood are directly related to intrauterine infection.