CD44v6和Galectin-3在宫颈癌中的表达及临床意义

目的探讨CD44v6和Galectin-3蛋白在宫颈癌的表达及临床意义。方法采用免疫组化法检测25例正常宫颈、45例CIN及83例宫颈癌组织中CD44v6和Galectin-3的表达,并分析其与临床病理特征的关系。结果 1在宫颈癌组织中CD44v6和Galectin-3阳性表达率分别为77.11%、81.93%,均显著高于CIN和正常宫颈组织（P〈0.05）;2CD44v6和Galectin-3表达与组织学分级、淋巴结转移相关（P〈0.05）,与其它临床病理参数无关（P〉0.05）;3CD44v6和Galectin-3蛋白表达呈显著正相关（r=0.415,P=0.000）。结论 CD44v6和Galectin-3蛋白的表达可能与宫颈癌的发生发展、浸润转移相关,联合检测可以为宫颈癌判断预后提供重要依据。

Expressions and Clinical Significances of CD44v6 and Galectin-3 in Cervical Carcinoma.

Objective To evaluate the expression of CD44v6 and Galectin-3 in cervical carcinoma and its clinical significance. Methods Expression level of CD44v6 and Galectin-3 proteins in cervical carcinoma were detected by immunohistochemical method in 25 normal cervix, 45cases CIN and 83cases cervical carcinoma, and analyzed the relation with clinical pathologic parameters. Results （1）The positive expression rate of CD4dv6 and Galectin-3 was 77.11% , 81.93 % , which was higher than that in CIN and normal cervix（ P 〈 0. 05 ）. （2）NF-KBp65 expression was significant correlation with the degree of histological grade and lymph node metastasis （P 〈 0.05 ）, but there was not obviously correlated with other clinical pathological parameters（P〉0.05）. （3）CD44v6 expression was positive correlated with Galectin-3 （r =0.415, P =0.000）. Conclusion The expression of CD44v6 and Galectin-3 protein were associated with the development and metastasis of cervical cancer. The combined detection of CD44v6 and Galectin-3 proteins can be used to provide an important basis for judge prognosis of cervical cancer.