| 急性心肌梗死合并糖尿病患者血清细胞凋亡因子sFas和sFasL的变化及意义 |
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| 引用本文： | 曹树军,程国杰,崔亮.急性心肌梗死合并糖尿病患者血清细胞凋亡因子sFas和sFasL的变化及意义[J].中国现代医药杂志,2008,10(7):22-24. |
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| 作者姓名： | 曹树军 程国杰 崔亮 |
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| 作者单位： | 1. 首都医科大学附属大兴医院心内科,北京,102600
2. 首都医科大学附属北京朝阳医院 |
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| 摘 要： | 目的了解糖尿病对急性心肌梗死患者血清细胞凋亡因子sFas和sFasL的影响。方法急性心肌梗死患者根据是否合并糖尿病将其分为非糖尿病组和糖尿病组。应用ELISA方法测定两组患者血清sFas和sFasL的含量。结果AMI合并DM患者血清sFas和sFasL的浓度明显高于非糖尿病患者,P〈0.01。心功能killip3/4级患者血清sFas和sFasL的浓度也高于killip1、2级患者,P〈0.05。结论急性心肌梗死合并糖尿病患者血清细胞凋亡因子sFas和sFasL的浓度高于非糖尿病患者。糖尿病可能通过促进Fas/FasL系统的激活而加速急性心肌梗死时心肌细胞凋亡的发生。
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| 关 键 词： | 急性心肌梗死 糖尿病 心肌细胞凋亡 Fas/FasL |
Change and significance of the sera apoptotic cytokines sFas and sFasL in patients with acute myocardial infarction and diabetes mellitus |
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| Cao Shujun,Cheng Guojie,Cui Liang.Change and significance of the sera apoptotic cytokines sFas and sFasL in patients with acute myocardial infarction and diabetes mellitus[J].Modern Medicine Journal of China,2008,10(7):22-24. |
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| Authors: | Cao Shujun Cheng Guojie Cui Liang |
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| Institution: | Cao Shujun,Cheng Guojie,Cui Liang.Department of cardiology,Daxing Hospital of Tthe Capital University of Medical Science,Beijing 102600 |
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| Abstract: | Objective To examine the effects of diabetes mellitus on the apoptotic cytokines of sFas and sFasL in the sera of patients with AMI. Methods Patients with AMI were divided into two groups: no diabetes mellitus and diabetes mellitus based on whether accompanied DM or not. Strepavidin-biotin ELISA was used to determine the serum levels of sFas and sFasL. Results The concentrations of sFas and sFasL in the sera of patients with AMI and DM were much higher than those of the patients who were AMI with no diabete... |
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| Keywords: | Fas/FasL |
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