血清甲状腺球蛋白抗体、甲状腺微粒体抗体、甲状腺过氧化物酶抗体对自身免疫性甲状腺疾病的诊断价值

目的探讨血清甲状腺球蛋白抗体（TGAb）、甲状腺微粒体抗体（TMAb）、甲状腺过氧化物酶抗体（TPOAb）对自身免疫性甲状腺疾病（AITD）的诊断价值。方法100例甲状腺功能异常患者根据血清中三碘甲状腺原氨酸（B）、甲状腺素（Td）、促甲状腺激素（TSH）水平分为甲亢组和甲减组，每组50例；另选择50例甲状腺功能正常人群作为对照组。各组患者均采集静脉血5mL，分离血清，放射免疫法测定患者血清中TGAb、TMAb、TPOAb、L、T4、TSH水平。观察各组患者血清中TGAb、TMAb、TPOAb阳性率；比较各组TGAb、TMAb、TPOAb阳性患者血清水平。结果甲亢组和甲减组血清TPOAb阳性率均明显高于血清TGAb、TMAb阳性率；甲亢组、甲减组患者血清TGAb、TMAb、TPOAb阳性率均明显高于对照组；甲减组患者血清TGAb、TMAb、TPOAb阳性率均明显高于甲亢组。甲亢组和甲减组患者血清TGAb、TMAb、TPOAb水平均明显高于对照组。甲减组患者血清中TGAb、TMAb、TPOAb水平均明显高于甲亢组。结论TPOAb在AITD的诊断中具有重要意义，为AITD的诊断、治疗及预后评估提供了重要依据。

Diagnostic value of serum thyroglobulin antibody,thyroid microsomal antibody and thyroid peroxidase antibody in autoimmune thyroid disease

Objective To explore the diagnostic value of serum thyroglobulin antibody （TGAb）, thyroid microsomal antibody （TMAb） and thyroid peroxidase antibody （TPOAb） in autoimmune thyroid disease （AITD）. Methods 100 patients with thyroid dysfunction were divided into hyperthyroidism group and hypothyroidism group according to the levels of serum triiodothyronine （T3）, thyroxine （T4） and thyroid stimulating hormone （TSH）, 50 cases in each group. Another 50 patients with normal thyroid function were collected and designed as control group. 5 mL venous blood was collected, and the serum was separated. The levels of TGAb, TMAb, TPOAb, T3, T4 and TSH were detected by radioimmunoassay in each group, positive rates of TGAb, TMAb and TPOAb were observed, and the serum levels of positive TGAb, TMAb and TPOAb were compared among all the groups. Results The positive rate of serum TPOAb was significantly higher than those of TGAb and TMAb in hyperthyroidism group and hypothyroidism group. The positive rates of serum TGAb, TMAb and TPOAb in hyperthyroidism and hypothyroidism groups were significantly higher than the control group, and those in hypothyroidism group were higher than hyperthyroidism group. The levels of serum TGAb, TMAb and TPOAb in hyperthyroidism group and hypothyroidism group were significantly higher than the control group, and those in hypothyroidism group were obviously higher than hyperthyroidism group. Conclusion TPOAb shows an important significance in diagnosing AITD, which provides an important evidence for AITD diagnosis, treatment and prognosis.