老年重叠综合征患者血清脑钠素水平的变化及其意义

目的观察单纯慢性阻塞性肺疾病（COPD）与COPD合并阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者,即重叠综合征（OS）患者体内血清脑钠素（BNP）水平的变化。方法回顾性分析2009年7月至2013年5月海军总医院呼吸内科住院患者113例,所有患者均经过完整的肺功能、动脉血气、超声心动图、夜间多导睡眠监测及血清BNP的检测。结果 COPD组（68例）与OS组（45例）患者的年龄、性别比例及身高体重指数（BMI）差异均无统计学意义（P〉0.05）;COPD组与OS组平均肺动脉压（m PAP）分别为（21.5±5.7）mm Hg和（29.2±6.3）mm Hg,OS组显著高于COPD组（P〈0.05）,而COPD组与OS组BNP平均浓度分别为（65.27±16.52）pm/ml与（98.59±27.38）pg/ml,两组比较差异也具有统计学意义（P〈0.05）。结论相对于单纯COPD患者,OS患者的平均肺动脉压和血清脑钠素水平更高。

Changes and significance of levels of brain natriuretic peptide in old patients with overlap syndrome

Objective To investigate the level of brain natfiuretic peptide （BMP） in old patients of chronic obstructive pulmonary diseases （COPD） and old patients of overlap syndrome [OS, COPD combined with obstructive sleep apnea-hypopnea syndrome （OSAHS）]. Methods A retrospective analysis was carried out for 113 patients aged over 60 years in Department of Respiratory Medicine of Navy General Hospital, who were tested for lung function, arterial blood analysis, echocardiography, polysomnography and BNP levels. Results There was no difference in age, gender ratio and body mass index between the COPD group （68 cases） and OS group （45 eases）. The mean pulmonary arterial pressure was （21.5±5.7） mmHg in COPD group, significantly lower than （29.2±6.3） mmHg in OS group （P〈0.05）. The average levels of BNP also showed statistically significant differences between the two groups, with （65.27±16.52） pg/ml in COPD group and （98.59±27.38） pg/ml in OS group. Conclusion Compared with COPD patients, mean pulmonary arterial pressure and brain natriuretic peptide levels of OS patients are higher.