胰腺癌患者联合检测CA19-9、CA125、CA242、CEA的临床意义

目的探讨胰腺癌患者联合检测血清糖抗原19-9（CA19-9）、癌胚抗原（CEA）、糖抗原125（CA125）及糖抗原242（CA242）的临床意义。方法选取2009年3月—2013年10月胰腺癌患者65例设为胰腺癌组,同期住院的良性胰腺病患者64例设为良性胰腺疾病组,同期健康体检者66例设为对照组。观察3组血清CA19-9、CEA、CA125、CA242水平差异,及单项检测和联合检测这4项指标诊断胰腺癌的敏感性和特异性。结果胰腺癌组血清CA19-9、CA125、CA242、CEA水平均显著高于胰腺良性疾病患组和对照组（P〈0.01）;联合检测4项指标的灵敏度为87.69%,特异度为91.54%。结论胰腺癌患者血清CA19-9、CEA、CA125、CA242表达水平显著上升,联合检测这4项指标对胰腺癌具有较高的诊断价值。

Clinical significance of combined detection of CA19-9,CA125,CA242 and CEA levels in patients with pancreatic cancer

Objective To explore the clinical significance of combined detection of serum carbohydrate antigen 19-9（CA-19-9）,carcinoembryonic antigen（CEA）,carbohydrate antigen 125（CA125） and carbohydrate antigen 242（CA242） in patients with pancreatic cancer. Methods 65 patients with pancreatic cancer were designed as pancreatic cancer group,another 64 patients with benign pancreatic disease and 66 healthy people with physical examinations at the same period were designed as benign pancreatic disease group and control group respectively. Serum CA19-9,CEA,CA125 and CA242 levels were observed among 3 groups,and the single and combined detection of the sensitivity and specificity of above 4 diagnostic indexes in detecting pancreatic cancer were conducted.Results Serum CA19-9,CEA,CA125 and CA242 levels were significantly higher in pancreatic cancer group than the other two groups（P〈0. 01）,and the sensitivity and specificity of combined detection of above 4 indexes were 87. 69% and 91. 54% respectively. Conclusion Serum CA19-9,CEA,CA125 and CA242 levels increase significantly in patients with pancreatic cancer,and their combined detection has a higher diagnostic value.