五味消渴方治疗气阴两虚证2型糖尿病患者临床观察

目的:观察五味消渴方治疗2型糖尿病气阴两虚证的临床疗效,并探讨其作用机制。方法:选取128例2型糖尿病气阴两虚证患者,随机分为治疗组(64例)和对照组(64例),治疗组采用五味消渴方+基础治疗,对照组采用安慰剂+基础治疗,观察治疗前后患者症状、体征变化,检测空腹血糖(FBG),餐后2 h血糖(P2 hBG),糖化血红蛋白(HbA1c),空腹血清胰岛素(FINS),安全性指标(血、尿、便常规,肝、肾功能),计算胰岛素抵抗指数(HOMA-IR),中医证候评分。结果:两组患者分配均衡,基线状况良好,可比性强。中医证候方面,两组患者口渴喜饮、多食易饥、气短懒言、倦怠乏力、心悸失眠、五心烦热、舌红少津、脉细数无力均明显改善,治疗组优于对照组(P0.05);治疗组和对照组中医疗效总有效率分别为93.55%,76.19%,治疗组优于对照组(P0.05);两组患者治疗后FBG,P2 hBG,HbA1c,FINS,HOMA-IR均较治疗前改善,治疗组改善更明显(P0.05)。结论:五味消渴方治疗2型糖尿病气阴两虚证疗效显著且安全,值得推广应用。

Clinical Observation of Wuwei Xiaoke Decoction in Treatment of Type 2 Diabetes with Qi and Yin Deficiency

Objective: To observe the effect of Wuwei Xiaoke decoction in treatment of type 2 diabetes with Qi and Yin deficiency. Method: A total of 128 patients with type 2 diabetes were selected and randomly divided into two groups:treatment group (64 cases) and control group (64 cases). Two groups were both treated with the basic therapy; the treatment group was additionally given Wuwei Xiaoke decoction, and control group was additionally given placebo. Clinical symptoms, sign changes, fasting blood glucose (FBG), postprandial 2 h blood sugar (P2 hBG), glycosylated hemoglobin (HbA1c), fasting insulin level (FINS), insulin resistance index (HOMA-IR), traditional Chinese medicine (TCM) syndrome score of two groups were observed after treatment. Result: Two groups were evenly distributed, with a good baseline status and strong comparability. In the aspect of TCM syndrome scores, treatment group was significantly better than control group in the alleviation of clinical symptoms (P<0.05). The total clinical effective rate was 93.55% in treatment group was significantly higher than control group (P<0.05). After treatment, two groups showed alleviations in FBG and P2 hBG, HbA1c, FINS and HOMA-IR, particularly the treatment (P<0.05). Conclusion: Wuwei Xiaoke decoction has a significant efficacy and safety in treating type 2 diabetes with Qi and Yin deficiency syndrome, and thus is worth clinical popularization.