High-dose intravenous IgG for chronic idiopathic thrombocytopenic purpura in adults |
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Authors: | J M Lang A Faradji C Giron J P Bergerat F Oberling |
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Institution: | (1) Service d'Onco-Hématologie, Hôpital de Hautepierre, F-67098 Strasbourg Cedex, France |
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Abstract: | Summary Sixteen adult patients of mean age 48 years with chronic ITP were studied for platelet response to high-dose (0.4 g/kg body weight per day for five consecutive days) intravenous polyvalent intact IgG in the absence of any concurrent treatment. The platelet count returned to normal values in nine patients, a partial response (rise in the platelet count between 50 and 150 ×109/l) was observed in three cases. One patient refractory to any other treatment went into a sustained remission. In the other responsive patients the response was only transient. Among seven splenectomised patients only three responded to IgG infusions versus nine in the non-splenectomised group. The length of ITP history appeared as a more critical factor for the response to IgG than previous splenectomy. |
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Keywords: | Chronic idiopathic thrombocytopenic purpura Intravenous IgG |
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