T-SPOT.TB联合ADA活性检测对结核性胸腔积液患者诊断效能的影响

目的:探讨T-SPOT.TB联合ADA活性检测对结核性胸腔积液患者诊断效能的影响。方法:选取2018年1月〜2020年6月我院结核性胸腔积液患者64例作为观察组,同期非结核性胸腔积液患者53例作为对照组。均行T-SPOT.TB、ADA活性检测,对比两组T-SPOT.TB、ADA水平,统计T-SPOT.TB、ADA单独及联合检测结果,分析二者联合检测对结核性胸腔积液诊断效能的影响。结果:观察组T-SPOT.TB阳性率、ADA水平高于对照组,差异有统计学意义(P<0.05);T-SPOT.TB单独检测阳性52例,阴性65例;ADA单独检测阳性55例,阴性62例;T-SPOT.TB联合ADA活,性检测阳性68例,阴性59例,T-SPOT.TB联合ADA活,性检测结核性胸腔积液的敏感度92.19%高于T-SPOT.TB 71.88%、ADA 75.00%单独诊断,漏诊率7.81%低于T-SPOT.TB 28.13%,ADA 25.00%单独诊断,差异有统计学意义(P<0.05);T-SPOT.TB联合ADA活性检测结核性胸腔积液的特异度、准确率、误诊率、阳性预测值、阴性预测值与T-SPOT.TB、ADA活性检测单独诊断对比,差异无统计学意义(P>0.05)。结论:结核性胸腔积液患者T-SPOT.TB、ADA水平升高显著,二者联合检测可进一步提高诊断效能,便于为临床鉴别诊断,制定治疗方案提供参考。

The effect of T-SPOT.TB combined with ADA activity detection on the diagnostic efficacy of tuberculous pleural effusion

Objective:To investigate the effect of T-SPOt test(T-SPOt.TB)combined with adenosine deaminase(ADA)test on the diagnostic efficacy of tuberculous pleural effusion.Methods:64 cases of patients with tuberculous pleural effusion in our hospital from January 2018 to June 2020 were selected as the observation group,and 53 patients with non-tuberculous pleural effusion in the same period were selected as the control group.T-spot.tb and ADA activity tests were performed in both groups.All patients were treated with TSPOT.TB Detection of ADA activity,Compare the two groups of T-SPOT.TB ADA level,Statistical t-SPOT.Results:TB of single and combined detection of ADA and ADA,Obj ective to analyze the effect of combined detection of the two on the diagnostic efficiency of tuberculous pleural effusion.Results The positive rate and ADA level of T-SPOt.TB in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.05).T-SPOt.TB was positive in 52 cases and negative in 65 cases.55 cases were tested positive whereas 62 cases were negative for ADA.The sensitivity of T-SPOt.TB combined with ADA to detect tuberculous pleural effusion was 92.19% which was higher than that of T-SPOt.TB(71.88%)and ADA(75.00%)respectively,and the rate of missed diagnosis was 7.81%which lower than that of T-SPOt.TB of 28.13% and ADA of 25.00%,was statistically significant(P<0.05).The difference of the comparison between T-SPOt.TB combined with ADA activity detection and T-SPOt.TB and ADA activity detection alone for tuberculous pleural effusion in specificity,accuracy,misdiagnosis rate,positive predictive value and negative predictive value was not statistically significant(P>0.05).Conclusion:T-SPOT.TB and ADA levels were significantly increased in patients with tuberculous pleural effusion.Combined detection of T-SPOt.TB and ADA levels could further improve the diagnostic efficacy and provide reference for clinical differential diagnosis and treatment planning.