经鼻蝶入路显微手术切除垂体生长激素腺瘤的疗效及免疫组化分析

目的观察分析不同临床类型及病理免疫组化分型的垂体生长激素(GH)腺瘤患者经鼻蝶入路显微手术的临床疗效。方法回顾性分析75例经鼻蝶入路手术治疗的垂体GH腺瘤的临床资料。结果术前GH平均值为40.79mIU/L,术后为19.48mIU/L。侵袭性腺瘤40例,非侵袭性腺瘤35例。侵袭性和非侵袭性腺瘤的术后症状缓解率分别为72.5%和88.6%,复发率分别为42.5%和14.3%。结论经鼻蝶入路显微手术对垂体GH腺瘤具有较高的临床症状和内分泌缓解率。侵袭性垂体GH腺瘤,缓解率较低,复发率高,单纯GH腺瘤侵袭性明显高于其他类型GH腺瘤。

Efficacy and immunohistochemical analysis of the transsphenoidal surgical resecting groeth hormone-secreting pituitary adenomas

Objective To observe and analyze the post-operation curative effects of different clinical and immunohistochemistry types in groeth hormone （GH）-secreting pituitary adenoma who underwent transsphenoidal surgery. Methods The clinical dates of 75 patients with GH-secreting pituitary adenoma treated by transsphenoidal surgery were analyzed retrospectively. Results The average pre-operational level of serous GH was 40.79mIU/L and the post-operational was 19.48mIU/L. Of 75 patients, there were 40 of invasive adenoma,and 35 were noninvasive. After the surgery,the remission rates of symptoms were 72.5% and 88.6% in invasive and noninvasive, and the recurrences were 42.5% and 14. 3%. Conclusions Transsphenoidal surgery for GH-secreting pituitary adenoma, which can remiss the symptoms effectively and has a high biochemical remission rate of GH-secreting. There are lower remission rates and higher recurrences in invasive carcinoma. The invasive tumor percentage of the simple GH-secreting pituitary adenoma is higher than that of the other pituitary adenomas.