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| 补肾中药组方对去卵巢大鼠骨微结构的影响 | |
| 引用本文： | 黄芳,汪家梨,姜小鹰,吴小南,曾毅丹. 补肾中药组方对去卵巢大鼠骨微结构的影响[J]. 中国老年学杂志, 2005, 25(7): 814-816 |
| 作者姓名： | 黄芳 汪家梨 姜小鹰 吴小南 曾毅丹 |
| 作者单位： | 1. 福建医科大学公共卫生学院,福建,福州,350004 2. 福建医科大学护理学院 |
| 基金项目： | 福建省科技计划项目(2001Z035) |
| 摘 要： | 目的研究补肾中药组方对去卵巢大鼠骨微结构的影响。方法通过卵巢摘除建立骨质疏松模型,研究不同剂量的补肾中药对去卵巢大鼠骨微结构的影响。结果光镜下观察高剂量补肾中药组方能改善去卵巢大鼠的骨小梁的分布、排列、之间的连接、厚度及间隙等组织学表现。组织计量学表明高、中剂量中药组能提高骨小梁TBV%和MTT(与OVX组比较P<0.05),这种功能与尼尔雌醇作用相当(P>0.05),低剂量中药组能提高骨小梁TBV%(与OVX组比较P<0.05)。结论补肾中药具有改善去势大鼠骨微结构的功能。 |
| 关 键 词： | 补肾中药 去卵巢大鼠 骨质疏松 组织形态学 |
| 文章编号： | 1005-9202(2005)07-0814-03 |
| 修稿时间： | 2005-01-14 |
The effect of Chinese kidney-tonifying drugs on bone histomorphometry of ovariectomized rats |
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| HUANG Fang,WANG Jia-Li,JIANG Xiao-Ying,et al.. The effect of Chinese kidney-tonifying drugs on bone histomorphometry of ovariectomized rats[J]. Chinese Journal of Gerontology, 2005, 25(7): 814-816 | |
| Authors: | HUANG Fang WANG Jia-Li JIANG Xiao-Ying et al. |
| Affiliation: | HUANG Fang,WANG Jia-Li,JIANG Xiao-Ying,et al .School of Public Health,Fujian Medical University,Fuzhou 350004,Fujian,China |
| Abstract: | Objective To study the effect of Chinese kidney-tonifying drugs on bone histomorphometry of ovariectomized rats. Methods Osteoporosis model was built by ovariectomized rats to explore the different dosages of Chines kidney-tonifying drugs on their bone histomorphometry. Results The distribution, arrangement, space and thickness of trabecular in ovariectomized rats were improved under light microscope. Histomorphometry showed that the trabecular bone volume (TBV%) and mean trabecular thickness value (MTT) were imcreased with high and moderate dosage of durgs, comparing to those of controls ( P<0.05 ), which had equivalent effect as nilestriol (P>0.05). The TBV% increased with low dosage of drug, compared to that in controls (P<0.05). Conclusions Chinese kidney-tonifying drugs could improve the bone histomorphometry of ovariectomized rats. |
| Keywords: | Chinese kidney-tonifying drugs Ovariectomized rat Osteoporosis Histomorphology |
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