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| 低抗凝肝素来源低分子肝素的研制及药代动力学 | |
| 引用本文： | 王福清 张天民. 低抗凝肝素来源低分子肝素的研制及药代动力学[J]. 中国药学杂志, 1994, 29(2): 99-101 |
| 作者姓名： | 王福清 张天民 |
| 作者单位： | 山东医科大学生化制药教研室 |
| 摘 要： | 以低抗凝肝素为来源，按生产要求设计工艺，制备了平均分子量为6000d的低分子肝素，测定了其理化指标、抗凝效价和抗FXa活性，研究了其抗血栓形成作用和药代动力学。结果表明，该低分子肝素具有较强的抗FXa活性和抗血栓形成作用，体内生物半衰期长。 |
| 关 键 词： | 低分子肝素 肝素 抗血栓形成作用 药代动力学 |
| 收稿时间： | 1992-12-23; |
The preparation of low molecular weight heparin from low anticoagulantactivity heparin and its pharmacokinetics |
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| WANG Fu-qing, ZHANG Tian-min, CUI Hui-fei, XU Li-xin. The preparation of low molecular weight heparin from low anticoagulantactivity heparin and its pharmacokinetics[J]. Chinese Pharmaceutical Journal, 1994, 29(2): 99-101 | |
| Authors: | WANG Fu-qing ZHANG Tian-min CUI Hui-fei XU Li-xin |
| Affiliation: | Shandong Medical University |
| Abstract: | A low molecular weight heparin(LMWH )with an average molecular weight of6000d was prepared by an established procedure. Its physical and chemical parameters,anticoagu-lant activity and anti-FXa activity were determined.The antithrombotic activity and pharma-cokinetics of the LMWH were also studied.The results showed that the product possessedstronger anti-FXa activity,antithrombotic activity,and longer biological half-life in vivo than thatof heparin. |
| Keywords: | low molecular weight heparin heparin antithrombotic activity pharmacokinetics |
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