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Oxidative Stress and Inflammation Are Differentially Affected by Atorvastatin,Pravastatin, Rosuvastatin,and Simvastatin on Lungs from Mice Exposed to Cigarette Smoke |
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| Authors: | Thiago Santos Ferreira Manuella Lanzetti Marina Valente Barroso Carlos Romualdo Rueff-Barroso Cláudia Farias Benjamim Lycia de Brito-Gitirana Luís Cristóvão Porto Samuel Santos Valença |
| Affiliation: | 1. Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil 2. Programa de Pós-gradua??o em Biologia Humana e Experimental, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil 3. Laboratório de Histologia Integrativa and LABCOM - ICB/CCS UFRJ, Av. Carlos Chagas Filho 373, Ilha do Fund?o, Rio de Janeiro, RJ 21941-902, Brazil |
| Abstract: | Our aim was to investigate the effects of four different statins on acute lung inflammation induced by cigarette smoke (CS). C57BL/6 male mice were divided into a control group (sham-smoked) and mice exposed to CS from 12 cigarettes/day for 5 days. Mice exposed to CS were grouped and treated with vehicle (i.p.), atorvastatin (10 mg/kg), pravastatin (10 mg/kg), rosuvastatin (5 mg/kg), or simvastatin (20 mg/kg). Treatment with statins differentially improved the pulmonary response when compared to the CS group. Atorvastatin and pravastatin demonstrated slightly effects on inflammation and oxidative stress. Rosuvastatin demonstrated the best anti-inflammatory effect, whereas simvastatin demonstrated the best antioxidant response. |
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