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湿疹溻渍方外用对模型小鼠的抗炎、止痒作用的实验研究
引用本文:闫英,;郭晓明,;武李莉,;郭泳君. 湿疹溻渍方外用对模型小鼠的抗炎、止痒作用的实验研究[J]. 北京中医药, 2014, 0(11): 861-864
作者姓名:闫英,  郭晓明,  武李莉,  郭泳君
作者单位:[1]北京中医药大学第三附属医院医疗处,北京100029; [2]黑龙江省大庆市龙南医院中医科,大庆163453; [3]北京市第一中西医结合医院人事科/皮肤科,北京100026; [4]北京中医药大学在读硕士研究生,北京100029
基金项目:北京中医药大学自主选题资助项目(JYB22-JS079)
摘    要:目的探讨自拟中药汤剂湿疹溻渍方外用对湿疹模型小鼠的作用机制。方法将7%、1%的二硝基氯苯(DNCB)-丙酮溶液分别涂抹在小鼠右耳部及腹部、背部脱毛皮肤,制作小鼠亚急性接触性湿疹模型,采用中药煎剂湿疹溻渍方进行溻渍洗浴治疗,观察小鼠右耳肿胀程度,计算两耳重量差、厚度差,观察小鼠右耳部皮肤组织病理真皮炎症细胞数的改变,记录小鼠10 min内舔体反应次数。结果湿疹溻渍方低、高剂量组均可抑制DNCB引起的小鼠耳部肿胀所造成的重量改变,与模型组比较差异有统计学意义(P〈0.05,P〈0.01);湿疹溻渍方低、高剂量组均可抑制4-氨基吡啶(4-AP)引起的小鼠舔体反应,与模型组比较差异有统计学意义(P〈0.05,P〈0.01)。结论湿疹溻渍方外用对小鼠湿疹模型有显著的治疗作用,其作用机制与抑制炎症反应和止痒有关。

关 键 词:湿疹  湿疹溻渍方  外用  抑炎症  止痒  小鼠

Effect of Eczema Tazi formula for external use on the anti-inflammation and relieve itching in mice
Affiliation:YAN Ying, GUO Xiao-ming, WU Li-li, GUO Yong-jun ( 1. Department of Medical Care, The Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing 100029, China; 2. Department of TCM, Daqing Longnan Hospital, Daqing 163453 ; 3. Personnel Office/Dermatology Department, The First Integrated Chinese and Western Medicine Hospital of Beijing, Beijing 100026; 4. Beijing University of Chinese Medicine, Beijing 100029)
Abstract:Objective To explore the action mechanism of self-made TCM decoction"Eczema Tazi formula"for external use on mice model of eczema. Methods 7%,1% DNCB—acetone solution was applied in mice right ear,abdomen and back hair to establish the subacute contact eczema model of mice. The traditional Chinese medicine "Eczema Tazi formula " was applied to perform bath treatment; the swelling degree of right ear was observed; the weight difference and thickness difference two ears were calculated;dermal inflammatory cell number of mice right ear was observed; 10-min licking response times was recorded. Results The low-dose and high-dose of " Eczema Tazi formula" could both inhibit the weight change of right ear swelling caused by DNCB,which had significant differences from model group( P〈0. 05,P〈 0. 01). The low-dose and high-dose of " Eczema Tazi formula" could both inhibit mice licking response induced by 4-aminopyridine,which had significant differences from model group( P〈0. 05,P 〈0. 01).Conclusion"Eczema Tazi formula"for external use has significant therapeutic effect on mice model of eczema,which may be related with inhibiting inflammatory reaction and relieving itching.
Keywords:eczema  Eczema Tazi formula  external use  anti-inflammatory  antipruritic  mice
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