| 柯里拉京对HSE炎性因子分泌和神经元凋亡影响的实验研究 |
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| 引用本文： | 张运康,陶连方.柯里拉京对HSE炎性因子分泌和神经元凋亡影响的实验研究[J].卒中与神经疾病,2011,18(6):357-360. |
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| 作者姓名： | 张运康 陶连方 |
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| 作者单位： | 湖北医药学院附属十堰市人民医院老年病科,十堰市,441000 |
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| 摘 要： | 目的探讨柯里拉京对单纯疱疹病毒型脑炎(HSE)炎性因子分泌和神经元凋亡的影响。方法建立HSV-1接种BV2细胞模型,随机分为正常组、单纯疱疹病毒1型(HSV-1)感染组、柯里拉京干预组、地塞米松干预组、黄芪多糖干预组,采用ELISA法检测各组炎性因子白细胞介素1β(IL-1β)、肿瘤坏死因子(TNF-a)的表达水平;25只Balb/c小鼠按上述分组分成五组,除正常组外其它各组应用HSV-1感染小鼠建立病毒性脑炎模型,治疗4d后采用TUNEL法观察各组小鼠神经元凋亡的情况。结果与病毒感染组比较,柯里拉京和地塞米松干预组HSV-1感染后IL-1b和TNF-a的分泌(P<0.01)和神经元凋亡数(P<0.01)均明显减少。结论柯里拉京可能通过减少HSV-1感染后IL-1b和TNF-a的分泌,并同时抑制神经元的凋亡来发挥其脑保护作用。
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| 关 键 词： | 柯里拉京 炎性因子 凋亡 单纯疱疹病毒1型脑炎 |
Experiment study of effect of Corilagin on HSE in production of inflammatory factor and neuronal apoptosis |
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| Zhang Yunkang,Tao Lianfang.Experiment study of effect of Corilagin on HSE in production of inflammatory factor and neuronal apoptosis[J].Stroke and Nervous Diseases,2011,18(6):357-360. |
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| Authors: | Zhang Yunkang Tao Lianfang |
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| Institution: | Zhang Yunkang,Tao Lianfang. Department of Geriatrics,the Affiliated Shiyan People's Hospital,Hubei Medical College,Shiyan 441000 |
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| Abstract: | Objective To investigate the effect of Corilagin on expression of inflammatory factor and neuronal apoptosis in Herpes simplex encephalitis(HSE). Methods The herpes simplex virus-1(HSV-1) infected BV2 cells model was built,and then randomly divided into five groups:control group,HSV-1infected group, HSV-1infected+Corilagin group,HSV-1infected+Dexanethasone group and HSV-1infected+Astragalus polysaccharide group.The contents of IL-1b and TNF-a secreted by microglia was detected by ELISA in each group,which r... |
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| Keywords: | Corilagin Inflammatory factor Apoptosis HSV-1 encephalitis |
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