Study of HLA antigens in familial and sporadic rheumatoid arthritis |
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| Authors: | M. A. Khan G. Kammer C. L. Dejelo I. Kushner W. E. Braun S. P. Ballou |
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| Affiliation: | Department of Medicine, Case Western Reserve University at Cleveland Metropolitan General Hospital, Cleveland, Ohio;Department of Immunopathology, Cleveland Clinic Foundation, Cleveland, Ohio;Department of Medicine, Case Western Reserve University at University Hospitals of Cleveland, Cleveland, Ohio, U.S.A. |
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| Abstract: | ![]()
Patients with familial and non-familial (sporadic) forms of rheumatoid arthritis (RA) were studied to investigate possible HLA heterogeneity. HLA-DR4 was present in 75% of familial and 59% of sporadic RA patients. The frequency distribution of A2, B8, B27, Cw3 and DR3 differed somewhat between the two groups; however, the differences were not statistically significant in this small group of patients. Studies of a larger number of patients are indicated to explore the possibility of genetic subgroups in RA. |
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