| 雷帕霉素洗脱支架在血小板高度活化状态冠状动脉介入治疗的疗效评价 |
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| 引用本文： | 张庆成,张向峰,汪承炜,毕春晖. 雷帕霉素洗脱支架在血小板高度活化状态冠状动脉介入治疗的疗效评价[J]. 实用诊断与治疗杂志, 2009, 23(3) |
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| 作者姓名： | 张庆成 张向峰 汪承炜 毕春晖 |
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| 作者单位： | 武警上海总队医院心血管内科,上海市,201103 |
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| 摘 要： | 目的:评价雷帕霉素药物洗脱支架治疗冠心病并血小板高度活化状态冠状动脉狭窄的疗效。方法:回顾202例冠心病患者行冠状动脉内支架介入治疗,其中131例为冠心病并血小板高度活化状态,采用雷帕霉素药物洗脱支架治疗62例,采用普通支架治疗69例;71例为冠心病不伴血小板高度活化状态,均为雷帕霉素药物洗脱支架治疗。结果:随访12个月,冠心病并血小板高度活化状态雷帕霉素药物洗脱支架治疗组,心脏事件发生率8.06%,普通支架治疗组心脏事件发生率10.14%,2组比较差异有统计学意义(P<0.01)。血小板高度活化状态冠状动脉再狭窄率比较,雷帕霉素药物洗脱支架治疗组11.29%,普通支架治疗组15.94%,2组比较差异有统计学意义(P<0.01)。结论:雷帕霉素药物洗脱支架能有效防止血小板高度活化状态冠状动脉病变新生内膜增殖和再狭窄,提高冠状动脉支架术的成功率,降低心脏事件发生率。
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| 关 键 词： | 冠状动脉疾病 支架 血小板 活化状态 |
Evaluation of the effect of sirolimus-eluting stent on coronary artery disease with platelet hyper-activation |
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| ZHANG Qingcheng,ZHANG Xiangfeng,WANG Chengwei,et al.. Evaluation of the effect of sirolimus-eluting stent on coronary artery disease with platelet hyper-activation[J]. Journal of Practical Diagnosis and Therapy, 2009, 23(3) |
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| Authors: | ZHANG Qingcheng ZHANG Xiangfeng WANG Chengwei et al. |
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| Affiliation: | ZHANG Qingcheng,ZHANG Xiangfeng,WANG Chengwei,et al.Department of Cardiology,Shanghai Municipal Corps Hospital,Chinese People's Armed Police Forces,Shanghai 201103,China |
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| Abstract: | Objective To evaluate the effect of sirolimus-eluting stent on coronary stenosis in coronary artery disease with platelet hyper-activation.Methods Among 202 coronary artery disease patients undergoing percutaneous coronary intervention,131 patients were associated with platelet hyper-activation.Of these patients,sirolimus-eluting stent was applied in 62 cases,and bare metal stent was applied in 69 cases.Another 71 patients with non-platelet hyper-activation accepted sirolimus-eluting stent.Results During 12... |
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| Keywords: | Coronary artery disease stents platelet activation |
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