降钙素原在新生儿感染性疾病中的临床价值

目的:探讨降钙素原(PCT)在新生儿感染性疾病中的临床价值。方法:对104例住院新生儿进行PCT测定,将其分为重症感染、一般感染、非感染3组进行分析,并与C反应蛋白(CRP)、血培养进行比较。结果:PCT阳性率重症感染组为89.47%,一般感染组为42.58%,非感染组为19.23%,重症感染组PCT阳性率明显高于其他两组,三组比较差异有显著性(P=0.000)。以>2ng/L为临界值,诊断重症感染的敏感度为71.05%,特异度为93.94%。与CRP比较,PCT诊断重症感染的敏感度、特异度更高;与血培养比较,其阳性率更高。结论:PCT在新生儿细菌感染时会升高,重症感染时升高更明显,可作为新生儿感染的早期检测指标,与CRP相比,其优越性更明显,对新生儿重症感染如败血症等的诊断更有价值。

The value of procalcitonin (PCT) in neonatal infection disease diagnosis

Objective:To investigate the value of procalationin(PCT)in neonatal infection disease diagnosis.Methods:PTC was measured in 104 hospitalized neonates,according to the results,the 104 neonates were divided into three groups:severe infection group,general infection and non-infection group,then compared with C-reactive protein(CRP)and blood culture.Results:The positive rates of PCT in severe infection group,general infection and non-infection group were 89.47%,42.58% and 19.23%,respectively,the positive rate of severe group was significantly higher than that of the other two groups,there were significant differences among the three groups(P=0.000).If 2.0ng/L was taken as the critical value,PCT sensitivity and specificity in the diagnosis of severe infection were 71.05% and 93.94%.respectively compared with CRP,PCT sensitivity and specificity in the diagnosis of severe infection was much higher,compared with blood culture the positive rate of PCT was much higher.Conclusion:PCT is increaseing in bacterium infection disease of neonatal,it is increasing much higher in severe infection.Therefore,it can be used as a marker in the early stage of neonatal infection disease diagnosis.Its advantage more evident than CRP,it is more valuable in neonatal severe infection such as sepsis.