| 他巴唑对Graves病患者血清可溶性白细胞介素—6受体的影响 |
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| 引用本文： | 王加林,赵亚平.他巴唑对Graves病患者血清可溶性白细胞介素—6受体的影响[J].标记免疫分析与临床,1999,6(2):67-69. |
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| 作者姓名： | 王加林 赵亚平 |
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| 作者单位： | 江苏省淮阴市解放军第８２医院内分泌科 |
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| 摘 要： | ５２例Ｇｒａｖｅｓ病（ＧＤ）患者随机分两组，２６例接受他巴唑（ＭＭＩ）、另２６例接受ＭＭＩ加心得安治疗。应用酶联免疫吸附分析（ＥＬＩＳＡ），测定了未治疗期（第０周），部分缓解期（第２周）和缓解期（第６周）患者及２０名健康对照者血清可溶性白细胞介素－６受体（ｓＩＬ－６Ｒ）水平。
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| 关 键 词： | 白细胞介素－6 受体 他巴唑 突眼性甲状腺肿 |
Effect of Methimazole on Serum Soluble Interleukin-6 Receptor in Patients with Graves Disease |
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| Wang Jialin,Zhao Yaping,Zhou Wei et al..Effect of Methimazole on Serum Soluble Interleukin-6 Receptor in Patients with Graves Disease[J].Labeled Immunoassays and Clinical Medicine,1999,6(2):67-69. |
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| Authors: | Wang Jialin Zhao Yaping Zhou Wei |
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| Abstract: | Fifty-two patients with Graves disease(GD) were divided randomly into two groups.Twenty-six received methimazole(MMI) alone,another twenty-six received MMI plus propranolol.Serum soluble interleukin-6 receptor(sIL-6R) levels were determined using ELISA in 52 patients with GD at the 0wk(un-treatment),2wk(partial-remission),6wk(remission) and 20 healthy controls.The results showed:(1)in un-treatment and partial-remission Graves patients,serum sIL-6R levels of the MMI-treated group and MMI plus propranolol-treated group were much higher than those of healthy controls,respectively(P<0.01);(2)There were no differences in Serum sIL-6R levels between MMI-treated group and MMI plus propranolol-treated group;(3)Serum free T3,free T4 level in Graves patients had no correlation with serum sIL-6R.The results suggested that MMI should play the suppressive effect on the production of serum sIL-6R in Graves patients. |
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| Keywords: | Soluble interleukin-6 receptorGraves diseaseMethimazole |
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