运动再学习对猴脑缺血损伤后脑血流量的影响 |
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引用本文: | 尹勇,谷震,杨波,秦冬冬,潘雷,甘露,王廷华,胡新天,冯忠堂.运动再学习对猴脑缺血损伤后脑血流量的影响[J].中国康复,2012,27(2):83-85. |
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作者姓名: | 尹勇 谷震 杨波 秦冬冬 潘雷 甘露 王廷华 胡新天 冯忠堂 |
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作者单位: | 1. 昆明医学院第四附属医院康复医学科,昆明,650023 2. 中国科学院昆明动物研究所,昆明,650023 3. 昆明医学院神经科学研究所,昆明,650023 |
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基金项目: | 云南省科技厅-昆明医学院联合专项基金资助项目(2008CD37R).致谢:衷心地感谢中国科学院昆明动物研究所王正波博士、董锦润老师和吴晶老师在研究过程中所给予的大力帮助! |
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摘 要: | 目的:观察运动再学习疗法对脑缺血损伤后恒河猴脑血流量的影响。方法:通过电凝法阻断恒河猴右侧大脑中动脉M1段制备成脑缺血损伤模型,术后采用觉醒意识水平肌力训练、协调能力及任务定向训练等运动再学习疗法(MRP),单光子发射计算机体层摄影(SPECT)测定训练前后相关脑区脑血流量的变化。结果:MRP明显改善脑缺血损伤恒河猴的局部脑血流量,但不能改变脑缺血所致的右/左脑区脑血流量的不对称性。结论:MRP可以增加脑缺血损伤周围及相关脑区脑血流量,促进受损神经功能恢复。
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关 键 词: | 运动再学习疗法 恒河猴 脑缺血 脑血流量 |
Effect of Motor Relearning Program on Regional Cerebral Blood Flow (rCBF) of Rhesus Monkeys with Cerebral Ischemic Stroke |
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Institution: | YIN Yong,GU Zhen,YANG Bo,et al.(Department of Physical Medicine and Rehabilitation Medicine,the Fourth Affiliated Hospital of Kunming Medical University,Kunming 650023,China) |
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Abstract: | Objective: To observe the effect of motor relearning program(MRP) on regional cerebral blood flow(rCBF) of rhesus monkeys with cerebral ischemic stroke.Methods: Rhesus monkeys subject to an occlusion of the M1 segment of the right middle cerebral artery(MCA) by using electrocoagulation were trained with MRP,and single-photon emission computed tomography(SPECT) was used before and after MCA occlusion to semi-quantify the changes of rCBF.Results: MRP could greatly improve rCBF of the animals with cerebral ischemic stroke,but couldn't change the functional asymmetry of cerebral hemispheres.Conclusion: It is possible that MRP increases cerebral blood flow in injured areas and other related areas to have a significant improvement on neurological deficits caused by cerebral ischemia. |
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Keywords: | motor relearning program rhesus monkeys cerebral ischemia regional cerebral blood flow |
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