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Alpha fetoprotein in the antenatal diagnosis of the congenital nephrotic syndrome. |
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| Authors: | J Wiggelinkhuizen M M Nelson G M Berger R O Kaschula |
| Affiliation: | 1. Department of Radiology University of Texas Medical Branch, Galveston, Texas USA;2. Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas USA |
| Abstract: | In the congenital nephrotic syndrome (Finnish type), concentrations of alpha fetoprotein in the amniotic fluid and maternal serum are markedly elevated in the second trimester of pregancncy. Demonstration of this alteration allows early prenatal diagnosis of this fatal condition and elective termination of the pregnancy before 20 week's gestation. |
| Keywords: | Reprint address: Renal Clinic Red Cross War Memorial Children's Hospital Rondebosch Cape 7700 Republic of South Africa. |
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