| 甲氟哌啶抗实验性心律失常的研究 |
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| 引用本文： | 潘鑫鑫,陈京徽,陈舒,刘天培,区兆华,陆婉芳,孙祥祯,施耀增,陈子涛. 甲氟哌啶抗实验性心律失常的研究[J]. 南京医科大学学报(自然科学版), 1987, 0(3) |
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| 作者姓名： | 潘鑫鑫 陈京徽 陈舒 刘天培 区兆华 陆婉芳 孙祥祯 施耀增 陈子涛 |
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| 作者单位： | 南京医学院药理学教研室，南京医学院药理学教研室，南京医学院药理学教研室，南京医学院药理学教研室，南京大学化学系，南京大学化学系，南京大学化学系，南京大学化学系，南京大学化学系 |
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| 摘 要： | 口服甲氟哌啶25mg/kg,静脉注射甲氟哌啶15mg/kg,对恒速静脉注射哇巴因引起的豚鼠心律失常有对抗作用,口服甲氟哌啶50mg/kg能对抗氯化钙-乙酰胆碱引起的小鼠心律失常,并给缩短其心律失常持续时间,对抗此种心律失常的ED_(50)为5.64mg/kg,小鼠静脉注射甲氟哌啶的LD_(50)为35mg/kg。
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| 关 键 词： | 甲氟哌啶 氯化钙-乙酰胆硷 心律失常 豚鼠 |
EXPERIMENTAL SUTDY OF ANTIARRHYTHMIC EFFEECT OF MELPERONE |
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| Pan Xinxin,et al.. EXPERIMENTAL SUTDY OF ANTIARRHYTHMIC EFFEECT OF MELPERONE[J]. Acta Universitatis Medicinalis Nanjing, 1987, 0(3) |
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| Authors: | Pan Xinxin et al. |
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| Abstract: | Melperone at the dosage of 25mg/kg p.o.or 15mg/kg i.v. could antagonize the arrhythmia induced by ouabain i.v. infusion in guinea pigs Melperone 50 mg/fcg p.o. could also protect the heart from atrial fibrillation induced by CaCl_2Ach in mice and the duration of this kind of arrhythmia was shortened. The ED_(50) of the protection was 5.64mg/kg and LD_(60) was 35mg/kg. The results suggest that melperone administrated orally is also effective against arrhythmia. |
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| Keywords: | melperone antiarrhythmics arrhythmia guinea pigs |
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