乳腺癌眼转移的诊治探讨

目的探讨乳腺癌患者眼葡萄膜转移的诊治。方法回顾性分析重庆医科大学附属第一医院2007年1月至2011年8月收治的2400例乳腺癌中2例眼葡萄膜转移患者的症状、体征、辅助检查、诊治经过及预后等资料。结果2例均以视物模糊、视力下降为主要症状，行眼底检查、眼底血管荧光造影均为单眼脉络膜转移（发现率为0．08％）。例l在乳腺癌确诊前发现眼转移，例2在乳腺癌术后第4疗程辅助化疗期间发现眼转移。2例患者在治疗期均未见其他部位转移，予以TEC方案化疗后眼部症状明显改善。结论眼葡萄膜转移可发生在乳腺癌的各期；及时发现与诊治，可有效控制病变进展，保护视力和改善生活质量；乳腺癌患者尤其是出现视物模糊、视力下降等眼部症状时应行眼部检查。

Diagnosis and treatment of uveal metastasis in patients with breast cancer

Objective To study the occurrence,diagnosis and treatment of uveal metastasis in patients with breast cancer.Methods In 2400 cases of breast cancer patients,2 cases of uveal metastasis admitted from Jan.2007 to Aug.2011 in our hospital were retrospectively analyzed to study the occurrence,diagnosis and treatment.Results Both the 2 cases had the symptoms of blurred vision and hypopsia.Fundus examination and funds fluorescein angiography showed that the 2 cases had unilateral choroidal metastasis with the discovery rate of 0.08％.Case 1 was found to have uveal metastasis before breast cancer was confirmed and case 2 was found to have uveal metastasis during the 4th chemotherapy cycle.No other distant metastasis was found in these 2 patients.The eye symptoms improved obviously after chemotherapy.Conclusions In order to get a good therapeutic effect for breast cancer patients with uveal metastasis,we should pay attention to patients' symptoms and signs.Eyes examination should be taken when patients have eye symptoms and signs.