新活素对急性心肌梗死伴心力衰竭患者炎症因子的影响

目的：探讨新活素对急性心肌梗死（AMI）伴心力衰竭患者炎症因子的影响。方法：AMI合并心力衰竭患者70例,随机分为常规治疗组（n=35）和新活素治疗组（n=35）,分别测定治疗前后血清肿瘤坏死因子（TNF-α）、C反应蛋白（CRP）及白介素-6（IL-6）水平,并记录2组治疗前及治疗后1个月时的左室射血分数（LVEF）、左室舒张末期容积指数（LVEDVI）、左室收缩末期容积指数（LVESDVI）。结果：新活素治疗组治疗后血清TNF-α、CRP及IL-6水平较治疗前均明显下降（P〈0.05）,且明显低于常规治疗组治疗后（P〈0.05）。新活素治疗组治疗后1个月超声心动图相关指标改善优于同期常规治疗组（P〈0.05）。结论：新活素能在一定程度上减轻AMI伴心力衰竭患者心肌的炎症反应,改善心功能。

Effect of rhBNP on Inflammatory Factors of Patients With Acute Myocardial Infarction Complicating Heart Failure

Objective：To explore the effect of rhBNP on inflammatory factors of patients with acute myocardial infarction（AMI） complicating heart failure（HF）.Methods：Seventy patients with AMI complicating HF were randomly divided into routine treatment group（n=35） and rhBNP treatment group（n=35）.Serum levels of TNF-α,CRP and IL-6 were measured before and after treatment.Echocardiogram indices（LVEF,LVEDVI,LVESDVI） were recorded before treatment and one month after treatments.Results：Serum levels of TNF-α,CRP and IL-6 decreased significantly after treatment in rhBNP treatment group（P0.05）,and they were significantly lower than those in routine treatment group after treatment（P0.05）.The improvement of echocardiogram indices was superior in rhBNP group to routine treatment group one month after treatment（P0.05）.Conclusion：rhBNP could alleviate inflammatory injury of myocardium in patients with AMI complicating HF to some extent,and it might improve heart function.