肿瘤免疫抑制微环境对肿瘤免疫治疗作用的研究进展

肿瘤免疫抑制微环境是肿瘤微环境中起抑制免疫功能的部分。其组成包括抑制性细胞和抑制性细胞因子。近年来，因其在肿瘤免疫中的重要作用，CAR－T和PD－1／PD－L1信号通路已成为免疫治疗的研究热点，它们可通过不同的机制产生免疫抑制作用，从而促进肿瘤进展。因此，针对以上机制采取更有效的抗肿瘤疗法有可能减缓肿瘤进展。本文现就免疫抑制微环境对CAR－T疗法和PD－1／PD－L1信号通路在抗肿瘤过程中的作用进行综述。

Study progresses of tumor immunosuppressive microenvironment in tumor immunotherapy

Immunosuppressive tumor microenvironment is a part of the tumor microenvironment that plays an immunosuppressive function.It consists of suppressor cells and inhibitory cytokines.In recent years,be-cause of its important role in tumor immunity,CAR-T and PD-1/PD-L1 signal pathway has become a hot top-ic of immunotherapy, which can suppress immune through different mechanisms to promote tumor progression. Therefore,taking more effective anti-tumor therapies against the above mechanisms is possible to rescue the pro-gress of tumor.In this article,the influence of immunosuppression microenvironment in CAR-T cell therapy and PD-1/PD-L1 signaling pathway in the anti-tumor process is reviewed.