| 促红细胞生成素对脑缺血再灌注损伤保护作用的研究 |
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| 引用本文： | 叶世武,汤永红,李赟.促红细胞生成素对脑缺血再灌注损伤保护作用的研究[J].国际神经病学神经外科学杂志,2009,36(5):391-394. |
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| 作者姓名： | 叶世武 汤永红 李赟 |
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| 作者单位： | |
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| 摘 要： | 目的探讨促红细胞生成素在脑缺血再灌注损伤中的保护作用及其可能的机制。方法采用Zea Longa改良线栓法制作局灶性大鼠脑缺血再灌注损伤模型。取健康成年雄性SD大鼠60只,随机分为正常组、假手术组、缺血再灌注组和EPO干预组,每组15只大鼠。EPO干预组分别于缺血前2h、缺血后6h、缺血后24h予以EPO 3000 IU/kg腹腔注射。缺血再灌注组、假手术组和正常组于相应时间给与等量生理盐水。再灌注72h后进行神经功能缺损评分,检测Nissl小体、脑红蛋白(NGB)和单核细胞趋化蛋白-1(MCP-1)的表达。结果与缺血再灌注组比较,EPO干预组的神经功能明显改善。EPO干预组Nissl小体减少的程度较轻。EPO干预组的NGB表达明显高于缺血再灌注组(P<0.01);而EPO干预组的MCP-1表达明显低于缺血再灌注组(P<0.01),均以缺血前2hEPO干预亚组明显。结论EPO可能通过上调NGB和下调MCP-1表达而减轻脑缺血再灌注损伤。
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| 关 键 词： | 促红细胞生成素 缺血再灌注 Nissl小体 脑红蛋白 单核细胞趋化蛋白 大鼠 |
| 收稿时间： | 2009/7/11 0:00:00 |
| 修稿时间： | 2009/10/12 0:00:00 |
Study the protective effects of erythropoietin cerebral ischema-reperfusion injury |
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| YE Shi-Wu,TANG Yong-Hong,LI Yun.Study the protective effects of erythropoietin cerebral ischema-reperfusion injury[J].Journal of International Neurology and Neurosurgery,2009,36(5):391-394. |
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| Authors: | YE Shi-Wu TANG Yong-Hong LI Yun |
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| Institution: | YE Shi-Wu,TANG Yong-Hong,LI Yun. Department of Neurology,The Second Affiliated Hospital of Nanhua University,Hengyang,Hunan 421001,China |
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| Abstract: | Objective To investigate protection of erythropoietin (EPO) against cerebral ischemia-reperfusion injury in rats and possible mechanisms. Methods The model of focal cerebral ischemia-reperfusion injury was prepared by occluding middle cerebral artery. Sixty male adult SD rats were randomly divided into four groups (n=15 each): normal,sham-operated,ischemia-reperfusion and EPO-treated. The EPO treated group received an intraperitoneal injection of rHu-EPO (3000 IU/kg) 2 hrs before and 6 hrs and 24 hrs after ... |
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| Keywords: | erythropoietin cerebral ischemia-reperfusion Nissl body neuroglobin monocyte chemoattractant protein-1 rat |
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