初诊2型糖尿病患者胰岛素抵抗与颈动脉内膜中层厚度的相关研究

目的:研究胰岛素抵抗与颈动脉内膜中层厚度的关系。方法:选择72例初诊2型糖尿病患者(糖尿病组)和28例健康者(对照组),测定空腹血糖(FPG)、糖化血红蛋白(HbA1c)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹胰岛素(FINS),并计算体重指数(BMI)、稳态模型评估法计算胰岛素抵抗指数(HOMA-IR),用彩色多普勒超声仪检测颈动脉内膜中层厚度(IMT)。结果:糖尿病组IMT较对照组升高,糖尿病组中IMT增厚组FINS、HOMA-IR较IMT正常组升高,差异有统计学意义(P<0.05)。IMT与年龄、BMI、FINS、ln(HO MA-IR)、LDL-C呈正相关(P<0.05)。结论:初发T2DM患者中已存在颈动脉IMT增厚,IR和高胰岛素血症是导致T2DM早期动脉粥样硬化(AS)的重要因素。

Study on the relationship of carotid artery intima-media thickness and insulin resistance in newly diagnosed type 2 diabetic patients

Objective To investigate the relationship of carotid artery intima-media thickness(IMT) and insulin resistance(IR).Methods 72 newly diagnosed type 2 diabetic patients(diabeties group) and 28 healthy people(control group) were enrolled in this study.Test fasting blood glucose(FBG),glycosylated hemoglobin(HbA1c),triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),fasting blood insulin(FINS);Calculate the body mass index(BMI);evaluate the homeostasis model assessment of IR(HOMA-IR);detect carotid artery IMT with color Doppler ultrasound.Results The carotid artery IMT in diabeties group was higher than control group;and in diabeties group,cases with thickened IMT had higher FINS and HOMA-IR.The differences were significant(P<0.05).Conclusions The thickening of the carotid artery IMT has already existed in patients with newly diagnosed T2DM.IR and Hyperinsulinemia are important factors causing early arterial atherosclerosis in patients with T2DM.